Vitamin C Injection

Active Ingredients: Vitamin C (Ascorbic Acid)

Vitamin C Injection is a sterile parenteral formulation of ascorbic acid intended for human use. Parenteral vitamin C may be required when clinically significant vitamin C deficiency or scurvy needs treatment and oral administration is not possible, insufficient, or contraindicated.

Vitamin C, also known as L-ascorbic acid or ascorbate, is an essential water-soluble vitamin that humans cannot synthesize endogenously. It acts as a cofactor in several enzymatic processes and is required for normal collagen biosynthesis. Vitamin C also contributes to antioxidant defense, carnitine and neurotransmitter synthesis, and the absorption of non-heme iron.

Adequate vitamin C is particularly important for connective-tissue integrity and wound healing. Severe or prolonged deficiency can impair collagen formation and result in scurvy, which may present with fatigue, gingival changes, petechiae, bruising, poor wound healing, joint symptoms, and other manifestations of connective-tissue weakness.

Vitamin C Injection is available in several concentrations to support different clinical and market requirements:

• 100mg/2ml
• 250mg/2ml
• 500mg/2ml
• 500mg/5ml

The solution is supplied in ampoules, with packaging options of 10 or 100 ampoules per box.

For patients who can receive enteral therapy, oral vitamin C is generally preferred. AdvaCare Pharma also supplies Vitamin C Tablets and a broader portfolio of vitamin C nutritional products for markets requiring alternative dosage forms.

As a global pharmaceutical supplier, AdvaCare Pharma provides Vitamin C Injection as part of its extensive range of small-volume injectable medicines. Production, quality-control procedures, regulatory documentation, and packaging configurations are adapted to the requirements of destination markets and pharmaceutical distributors.

AdvaCare Pharma is a manufacturer and global supplier of Vitamin C Injection for human use. Our pharmaceutical injections are produced in GMP-compliant manufacturing facilities using controlled production processes designed to support product quality, consistency, sterility, and compliance with destination-market requirements.

Vitamin C Injection is offered in four strengths — 100mg/2ml, 250mg/2ml, 500mg/2ml, and 500mg/5ml — providing pharmaceutical distributors with formulation options suitable for different registration and market requirements.

As part of our portfolio of more than 120 pharmaceutical injection products, Vitamin C Injection is supported by AdvaCare Pharma's experience supplying medicines to over 65 international markets. Our distribution partners benefit from regulatory support, technical documentation, adaptable packaging, and a broad pharmaceutical portfolio designed to simplify healthcare procurement and product sourcing.

What is Vitamin C used for?

Vitamin C Injection is used for parenteral replacement of vitamin C in patients with clinically significant deficiency, including scurvy, particularly when oral vitamin C therapy cannot be used, is insufficient, or is contraindicated.

Scurvy develops when prolonged vitamin C deficiency interferes with normal collagen synthesis. Clinical manifestations may include fatigue, easy bruising, petechiae, swollen or bleeding gums, impaired wound healing, joint discomfort, and connective-tissue abnormalities.

The precise approved indication may vary according to the product registration and prescribing information in each market.

High-dose intravenous vitamin C has also been investigated in clinical research, including oncology studies. These investigational uses should not be confused with the approved indications of standard Vitamin C Injection. High-dose intravenous vitamin C is not an established substitute for standard cancer treatment and is not FDA-approved as a cancer therapy.

How are Vitamin C Injections used?

Vitamin C Injection is a sterile solution intended for parenteral administration by a qualified healthcare professional.

The approved route of administration should follow the product information registered in the destination market. Depending on the formulation and local labeling, ascorbic acid injections may be administered intravenously or by another approved parenteral route.

When intravenous infusion is required, the product should be prepared and diluted according to its approved prescribing information. Concentrated ascorbic acid solutions should not be given as rapid intravenous injections.

Before administration, the ampoule and solution should be visually inspected. Products showing unexpected discoloration, visible particulate matter, damaged containers, or evidence of contamination should not be used.

Ascorbic acid is chemically reducing and may be incompatible with certain substances. Compatibility should therefore be confirmed before combining Vitamin C Injection with other medicines or infusion solutions.

How should Vitamin C Injections be stored?

Store unused Vitamin C Injection at 2–8°C and protect the ampoules from excessive light and heat, unless otherwise specified by the approved product labeling for the destination market.

Ampoules should remain in their original packaging until required for use. Do not use an ampoule if it is cracked, leaking, or otherwise damaged.

Local product labeling and transport requirements should always be followed throughout storage and distribution.

What environmental factors contribute to the rapid degradation of Vitamin C in injection form?

Ascorbic acid is sensitive to oxidation. Exposure to light, elevated temperatures, oxygen, and certain metal ions can accelerate degradation of vitamin C solutions.

Protective pharmaceutical packaging, including light-resistant or amber glass where applicable, helps reduce light exposure during storage. Maintaining the specified storage conditions is important for preserving the stability and quality of the injectable solution throughout its shelf life.

Healthcare professionals should also inspect ampoules before use to confirm container integrity.

What dose should be given?

The dose of Vitamin C Injection depends on the patient's age, clinical indication, severity of deficiency, route of administration, renal function, treatment response, and the concentration of the product being used.

Dosage should always follow locally approved prescribing information.

For reference, current U.S. prescribing information for intravenous ascorbic acid used for short-term treatment of scurvy recommends the following once-daily doses: Adult Dosing For the short-term treatment of scurvy, the usual dose is 200mg IV, given daily for 1 week until the resolution of scorbutic symptoms. Alternatively, 100-250mg IM/IV/SC can be given every 1 to 2 days. The maximum dosage is 6g in 24 hours. For patients with G6PD (glucose-6-phosphate dehydrogenase) deficiency, a decreased dose should be considered.

For pediatric patients with G6PD deficiency, a decreased dose should be considered.

The referenced regimen has a maximum recommended treatment duration of seven days, with further treatment determined according to the clinical response. Repeat dosing is not recommended in children younger than 11 years under that particular prescribing information.

These doses should not automatically be applied to every Vitamin C Injection formulation or market. Healthcare professionals should refer to the approved prescribing information supplied with the registered product.

Who can use Vitamin C?

Vitamin C Injection may be prescribed to adults and pediatric patients when parenteral vitamin C therapy is clinically indicated. Suitability depends on the patient's age, medical condition, renal function, nutritional status, and the locally approved product information.

Pregnant Vitamin C is an essential nutrient during pregnancy, but parenteral treatment should be used only when clinically indicated. There are limited data specifically evaluating intravenous ascorbic acid during pregnancy. The prescribing clinician should assess the expected benefit and potential risk and select an appropriate dose.

Breastfeeding Vitamin C is normally present in human milk. Data specifically evaluating maternal intravenous vitamin C administration during breastfeeding are limited. The clinical need for parenteral therapy, dosage, and potential risks should be assessed by a healthcare professional.

Children Pediatric administration should be based on age and approved prescribing information. Some regulatory labeling for intravenous ascorbic acid includes patients from 5 months of age. Very young children, particularly those younger than 2 years, may be more susceptible to oxalate nephropathy because of immature renal function and may require additional monitoring.

Geriatric Vitamin C Injection can be used in older patients when clinically indicated. Because renal function commonly declines with age, older patients may have an increased risk of oxalate accumulation or oxalate nephropathy. Renal function and other risk factors should therefore be considered before and during treatment.

What are the signs of an overdose of Vitamin C?

Excessive or prolonged administration of vitamin C may lead to gastrointestinal symptoms such as nausea, abdominal discomfort, or diarrhea.

High parenteral doses may increase urinary oxalate concentrations and contribute to hyperoxaluria, nephrolithiasis, or oxalate nephropathy, particularly in susceptible patients.

Hemolysis is a potentially serious complication in patients with G6PD deficiency who receive excessive doses of ascorbic acid.

If overdose is suspected, administration should be stopped and the patient should receive appropriate medical assessment and supportive treatment.

Other warnings

Prolonged treatment or unnecessarily high doses of parenteral vitamin C should be avoided unless specifically indicated and medically supervised.

Acute and chronic oxalate nephropathy have been reported following prolonged administration of high-dose ascorbic acid. Particular caution is required in patients with renal impairment or a history of oxalate kidney stones.

Patients with G6PD deficiency are at increased risk of hemolysis. Appropriate dose reduction and monitoring of hemoglobin and blood-cell counts may be required.

Vitamin C Injection should not be administered intravenously at an excessively rapid rate. Rapid intravenous administration has been associated with temporary faintness, nausea, flushing, dizziness, lethargy, and headache.

Because vitamin C may interfere with certain laboratory tests, healthcare professionals and laboratory personnel should be informed when a patient has recently received parenteral ascorbic acid.

As with all pharmaceuticals, some unwanted effects can occur from the use of Vitamin C Injection.

The risk of renal complications is greater with excessive doses, prolonged administration, or in patients with pre-existing renal disease or a history of oxalate stones.

For a comprehensive understanding of potential adverse effects and appropriate clinical monitoring, consult the approved product information or a qualified healthcare professional.

Seek medical attention if a serious or unexpected reaction occurs.

Vitamin C Injection should be administered under the supervision of a qualified healthcare professional. Before treatment, inform the prescribing clinician about all medicines, supplements, and medical conditions, particularly kidney disease, a history of renal or oxalate stones, glucose-6-phosphate dehydrogenase (G6PD) deficiency, or disorders involving abnormal iron accumulation.

High doses or prolonged parenteral administration of ascorbic acid may increase urinary oxalate and have been associated with oxalate nephropathy and nephrolithiasis. Patients with renal impairment, previous oxalate kidney stones, older patients, and young children may be at increased risk. Renal function should be assessed and monitored when clinically appropriate.

Patients with G6PD deficiency may have an increased risk of hemolysis after parenteral ascorbic acid, particularly at higher doses. Dose reduction and hematological monitoring may be required according to the approved prescribing information.

Ascorbic acid may interact with certain medicines. Reported interactions include some antibiotics, medicines whose elimination is affected by urinary pH, and warfarin. A healthcare professional should review concurrent medicines before treatment and determine whether additional clinical or laboratory monitoring is required.

Vitamin C is a strong reducing agent and may interfere with laboratory tests that rely on oxidation-reduction reactions. These can include some blood or urine glucose measurements, nitrite and bilirubin tests, and leukocyte-count methods. Where clinically appropriate, affected laboratory testing should be delayed until at least 24 hours after parenteral vitamin C administration.

Pregnant or breastfeeding patients should receive Vitamin C Injection only when clinically indicated and after assessment by a healthcare professional. Dose selection should follow the locally approved prescribing information and take the patient's nutritional requirements and medical condition into account.

Vitamin C Injection is not expected to directly impair the ability to drive or operate machinery. However, dizziness or faintness may occur if an intravenous formulation is administered too rapidly.

Ascorbic Acid Injection — Prescribing Information

The DailyMed prescribing information for Ascorbic Acid Injection provides detailed clinical guidance on the human use of parenteral ascorbic acid, including indications, preparation and administration, dosage, adverse reactions, drug interactions, and precautions.

The prescribing information identifies intravenous ascorbic acid as a short-term treatment for scurvy when oral therapy is not possible, insufficient, or contraindicated. It also describes clinically important risks including oxalate nephropathy, nephrolithiasis, hemolysis in patients with G6PD deficiency, and interference with laboratory testing.

It additionally provides age-specific dosing information and emphasizes appropriate dilution and slow intravenous administration.

Vitamin C — Fact Sheet for Health Professionals

The National Institutes of Health Office of Dietary Supplements Vitamin C fact sheet provides an evidence-based overview of the physiological functions, dietary requirements, deficiency, and health effects of vitamin C.

Vitamin C is an essential water-soluble nutrient required for collagen synthesis and several other enzymatic processes. It also functions as a physiological antioxidant and contributes to normal connective-tissue integrity and wound healing.

The review describes how progressive vitamin C deficiency can result in scurvy and associated manifestations including petechiae, bruising, gingival changes, joint symptoms, and impaired wound healing.

Vitamin C (Ascorbic Acid) — Clinical Review

The NCBI Bookshelf clinical review of Vitamin C (Ascorbic Acid) discusses vitamin C deficiency, scurvy, available dosage forms, administration, monitoring, and toxicity.

The clinical review describes oral therapy as appropriate for most patients while recognizing a role for parenteral administration when enteral treatment is unsuitable or absorption is impaired. It also discusses renal considerations and the risk of oxalate accumulation associated with excessive vitamin C exposure.