Promethazine Injection (box of 10 ampoules)
Promethazine Injection (box of 10 ampoules)
*Packaging color may differ according to distribution region.

Promethazine Injection

Promethazine Injection is an antihistamine for parenteral use. ISO and GMP guidelines are strictly followed by AdvaCare Pharma during the production of pharmaceutical injections, ensuring their safety.



What is Promethazine?

Therapeutic Class:

Active Ingredients: Promethazine

Promethazine Injection is used to control nausea and vomiting associated with operations, motion sickness, or other causes. This medication may be used with other drugs to treat severe allergic reactions, including anaphylaxis. It may also be administered to prevent some types of allergic reactions.

Promethazine is also indicated as a sedative to be used during medical procedures or childbirth. It is sometimes administered to improve the efficiency of some opioids, such as meperidine. Injections of Promethazine are typically given if a patient is unable to take this medication by mouth.

Promethazine is classified in the family of antihistamines known as phenothiazines. It is an H1-antagonist with anticholinergic, sedative, and antiemetic effects, and it also displays some local anesthetic properties. Promethazine works by blocking the effects of histamine.

AdvaCare is a GMP manufacturer of Promethazine Injections. This medication is produced in our factories in China, India, and the USA. We routinely inspect our production facilities to ensure our products meet quality and safety standards.

Why are we a leading Promethazine manufacturer?

AdvaCare Pharma is an American-owned pharmaceutical company that specializes in the manufacture of Promethazine Injection and other quality-assured injectable medications for the worldwide market. Over the past twenty years, we’ve built our reputation on reliable, efficacious, and affordable medical products and custom-tailored marketing plans to meet regional demands.


What is Promethazine used for?

It's used to treat or prevent some allergic reactions when oral antihistamines are unavailable. It is also used to treat or prevent nausea and vomiting associated with conditions like motion sickness or surgical procedures. Promethazine is also used as a sedative before surgery or labor and delivery.

How are Promethazine Injections used?

This medication has been manufactured as a clear, colorless solution. Each ml of solution contains 25mg of promethazine. It is intended to be administered by IM/IV injection by a healthcare professional in a hospital or clinic setting.

When giving a Promethazine Injection, it is especially important to monitor cardiac function, potassium concentration, and acid-base balance. It should not be infused rapidly to avoid potassium intoxication. Do not use other potassium-containing salt substitutes when using potassium chloride injection.

What dose should be given?

The usual dose for adults and children is dependent on the medical condition and weight. It is recommended to not exceed 10mEQ/hour or 200mEQ/day if the patient's potassium level is greater than 2.5mEQ/liter.

Side Effects

As with all pharmaceuticals, some unwanted effects can occur from the use of Promethazine Injection.

Common side effects include, but may not be limited to:

  • dizziness
  • drowsiness
  • swelling near the injection site

Serious side effects may include:

  • signs of an allergic reaction
  • tissue damage
  • seizures
  • changes in heart rate

For a comprehensive list of all side effects, consult a doctor or pharmacist.

If any symptom persists or gets worse, or you notice any other symptoms, please call your doctor.


Do NOT use Promethazine Injection if:

  • You are allergic to promethazine Injection or any other containing ingredients.
  • You are allergic to ester-group local anesthetics or substitute products in para of parahydroxybenzoate type.

Promethazine Injections should not be administered to children under 2 years old because of the risk of fatal respiratory depression.

This drug can also affect potassium levels, so it is important to monitor potassium levels when using this medication.

*Regulatory compliance may vary according to production standard, import requirements and/or manufacturing origin.

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Why AdvaCare Pharma?

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