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      *AdvaCare Spironolactone Capsules are GMP certified.

      **AdvaCare Spironolactone Capsules are manufactured in our facilities located in China/India/USA.

      (choose the specifications you require below)
      Dosage:

      50mg

      *or according to the distributor/ marketers requirements
      Packaging:

      10 capsules/blister, 1 blister/box

      *or according to the distributor/ marketers requirements
      Therapy:

      Potassium-sparing diuretic

      Active Ingredients:

      Spironolactone

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        Product Information

        General Information:
        AdvaCare is a GMP manufacturer of Spironolactone capsules

        Spironolactone is a potassium-sparing diuretic also referred to as ’water tablets’. Spironolactone capsules exact their actions by blocking the actions of the hormone aldosterone. Aldosterone is produced in the kidneys and adrenal gland is responsible for its production.

        Aldosterone acts on the kidney by balancing the equilibrium between salt and water in the body.

        Blocking this hormone (aldosterone) makes the kidneys to increase the number of salts it filters out of the blood, and into the urine.

        When salts (e.g. sodium) are filtered out of the blood, water is drawn alongside it. The action of spironolactone increases the amount of water that is drawn out of the blood; with this, excess fluid is removed from the system.

        The conditions that require this mechanism of action ranges from heart failure, liver cirrhosis, certain types of kidney disease and other systemic conditions that cause excessive fluid build-up in the body. Spironolactone renal action peaks after 7 hours and persists for at least 24 hours; it is excreted in the urine and feces in the form of metabolites.

        Side Effects:
        As with all pharmaceutical medicines, some unwanted effects can occur from the use of spironolactone capsules. Always consult a physician for medical advice before use.

        Common side effects may include abdominal cramps, diarrhea, leg cramps, dizziness, drowsiness, itching, high potassium levels, and irregular menstrual cycle. Some serious side effects include electrolyte/fluid problem, dangerously high potassium levels, allergic reactions, gynecomastia, and severe skin reactions. For a comprehensive list of all possible effects, consult your doctor. If any symptom persists or gets worse, or you notice any other symptoms, then please call your doctor immediately.

        Additional Information

        Always consult a medical doctor or patient care specialist before using spironolactone capsules.

        Indications and Usage

        Spironolactone is indicated in the management of liver diseases, nephrotic syndrome and hyperaldosteronism (excessive secretion of aldosterone). It is also used in managing heart failure, high blood pressure, and other arterial pressure abnormalities.

        Precautions

        Do not take spironolactone if:

        • You have severely decreased hepatic (liver) function;
        • You have severely decreased kidney function;
        • You have blood disorders like porphyrias;
        • You have anuria (inability of the kidneys to produce urine);
        • You have a high potassium level in your blood (hyperkalemia);
        • You have Addison’s disease;
        • You are allergic to spironolactone active ingredients.
        Administration and Dosage

        Use of spironolactone capsules during pregnancy or breastfeeding does not appear to be harmful. Consult with your doctor or health care professional before taking spironolactone.

        Refer to your doctor or pharmacist for guidelines on dosage. Do not exceed the advisable dosage. The usual dose for adults is 50-100mg per day. Adults with hyperaldosteronism may take up to 400mg per day for 3 to 4 weeks. Spironolactone capsules are not for use in children below 18 years of age.

        Interactions

        Possible interactions with spironolactone capsules include angiotensin-converting enzyme inhibitors (ACE inhibitors), angiotensin 11 receptor blockers (ARBS), direct renin inhibitors, eplerenone (this drug shouldn’t be used with spironolactone capsule), pain drugs, cholesterol drugs, digoxin, and lithium. Spironolactone capsules should not be taken with alcohol. Consult your doctor about any medications you are taking, before treatment with spironolactone capsules.

        Contraindications

        This medicine is contraindicated if:

        • You are below 18years;
        • You have severe and worsening liver/kidney damage;
        • You are pregnant/breastfeeding;
        • You are taking eplerenone;
        • You have not gotten guidelines from your doctor who knows your medical history.
        Overdose

        Taking more medicines may cause poisoning and serious side effects. Please call the emergency department if you suspect spironolactone capsules overdose.

        Adverse Reactions

        No adverse reactions have been reported.

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