Manufacturer of Antihistamines

AdvaCare Pharma is an established manufacturer of antihistamines intended for the treatment of conditions related to various types of allergies and hypersensitivities. Available in a variety of dosage forms, from tablets to nasal sprays.

Pharmaceuticals: Therapeutic Class

Dosage Form

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Azelastine HCL Nasal Spray
Betamethasone + Dexchlorpheniramine Maleate Tablets
Cetirizine HCL Syrup
Cetirizine Tablets
Chlorphenamine Injection
Chlorphenamine Maleate Tablets
Cyproheptadine HCL Syrup
Cyproheptadine Tablets
Desloratadine Syrup
Dimenhydrinate Injection
Dimenhydrinate Tablets
Diphenhydramine HCL + Zinc Acetate Cream
Diphenhydramine Oral Suspension
Levocetirizine Oral Suspension
Levocetirizine Tablets
Loratadine Oral Suspension
Loratadine Tablets
Meclizine + Vitamin B6 Tablets
Paracetamol + Chlorpheniramine Maleate Tablets
Promethazine HCL Syrup
Promethazine Injection
Sinus + Cold Tablets
Pharmaceutical manufacturer of tablets, capsules, injections, suspensions, creams, drops.


  • 9001
    Quality Management
  • 14001
    Environmental Management
  • 45001
    Occupational Health and Safety


  • GMP
  • ISO
  • FSC
  • COA
  • COO


  • CTD Dossier
  • Site Master File
  • Bioequivalence (BE) Studies

Manufacturing Locations

  • China, India, United States
*Regulatory compliance may vary according to production standard, import requirements and/or manufacturing origin.
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See why we are a leading manufacturer of pharmaceuticals.

AdvaCare is able to leverage raw materials, cost-effective processes and human resources to provide one of the most complete pharmaceutical ranges, competitive pricing and unmatched support, while always ensuring quality, accuracy and consistency.

Dr. D. Miller

Medical Advisory Board

What is the meaning of Antihistamines?

Antihistamines are a class of drugs used to treat allergy symptoms. Some indications include allergic rhinitis (hay fever), hives (urticaria), food allergies, and insect bites or stings. The symptoms that are eased through antihistamine medications may include itching, sneezing, runny nose, and watery eyes.

The efficiency of antihistamine drugs in alleviating symptoms of allergies, hypersensitivities, and other conditions is well established. Anti-allergy medications efficiently block the effects of histamine, a natural chemical mediator. With the body's reaction to allergens prevented, ensuing physical symptoms are also inhibited.

Antihistamine drugs are available in a variety of dosage forms including tablets, injections, syrups, nasal sprays and topicals.

What are Antihistamines used for?

What are Antihistamine Medicines used to treat?

Antihistamines treat many symptoms, including cold-like symptoms, allergic reactions, skin conditions, and much more. Although commonly administered in tablet dosage form for convenience, antihistamines are especially fast-acting as nasal sprays. Some specific conditions treated by allergy medications include: - Allergic reactions - Pruritus (Itching) - Sinusitis - Bronchitis - Hives (urticaria) - Eczema - Insomnia - Anxiety - Motion sickness - Nausea / vomiting - Peptic ulcer - Acid reflux

What is the mechanism of common Antihistamines?

Antihistamines are prescribed to treat histamine-caused symptoms. Histamine is released from mast cells; key effector cells of the immune system, in response to an allergen, or physical stimuli, such as trauma or temperature changes. It plays a crucial role in the pathophysiology of allergic and inflammatory reactions. The histamine binds to H1 receptors, allowing specialized cells and chemicals access to defend the body. This process causes unwanted symptoms.

Antihistamine medications function by inhibiting the binding of histamine to its H1 receptor on target cells, thereby preventing symptoms and promoting further histamine production.

Histamine is also found in the stomach to aid in producing acid for digestion. Therefore, antihistamine drugs are also used to alleviate nausea and other digestive-related symptoms.

When histamine binds to H2 receptors, it stimulates the production of stomach acid, which can cause irritation and inflammation in the lining of the digestive tract.

These antihistamine medicines bind to the H2 receptor, physically blocking histamine from interacting with the receptor. This prevents the downstream signaling that would otherwise result in increased acid secretion.

Types of Antihistamines

Antihistamines tend to treat a more specific range of indications and symptoms. However, there are still a few different types of allergy medications with mildly varying effects and uses. Here is a list of antihistamine types described in some detail.

H1 and H2 Blockers

Antihistamine medications are divided into two main groups: H1 receptor antagonists, or H1 blockers, and H2 receptor antagonists, or H2 blockers. H1 and H2 indicate the location of the histamine receptor that the antihistamine medication is designed to block.

H1 blockers prevent the action of histamine on H1 receptors in the body. These anti-allergy medicines are indicated for the treatment of allergic reactions, like hay fever, allergic rhinitis, and urticaria. They can also be used to manage symptoms of non-allergic conditions, such as motion sickness and insomnia. In some cases, H1 blockers may be used in combination with other medications to manage severe allergic reactions, such as anaphylaxis.

H2 blockers are prescribed to treat gastrointestinal conditions like gastroesophageal reflux disease (acid reflux), peptic ulcers, gastritis, and motion sickness.

First-Generation Antihistamine Medications

Both first and second-generation antihistamine drugs are H1 receptor antagonists. First-generation antihistamines, also known as sedating antihistamines, such as diphenhydramine and chlorpheniramine, work - as already described - by blocking H1 receptors in the central nervous system. Sedating antihistamine drugs also have sedative properties because they can cross the blood-brain barrier and bind to other receptors, such as muscarinic and alpha-adrenergic receptors.

First-generation antihistamine medicines are effective for treating mild to severe allergic conditions of different origins. However, they are also associated with several side effects, including sedation, dizziness, dry mouth, blurred vision, and constipation. They can also lead to impaired coordination and cognitive function, making them unsuitable for use before driving or operating machinery. Therefore, their use is generally reserved for short-term treatment of acute allergic reactions or for use at night to aid sleep in patients with allergies. Diphenhydramine, chlorpheniramine, hydroxyzine and promethazine can be listed as the examples of first-generation antihistamines.

Second-Generation Antihistamine Medications

Second-generation antihistamines, also known as non-sedating antihistamines, such as loratadine and fexofenadine, have the same mechanism as first-generation antihistamine drugs. However, they work more selectively, blocking histamine receptors without crossing the blood-brain barrier, resulting in fewer side effects than first-generation antihistamine medicines.

With fewer side effects, second-generation antihistamines for allergies are a preferred choice for the management of various allergy-associated conditions such as nasal congestion, runny nose, watery eyes, and sneezing. Cetirizine, loratadine and their derivatives are widely used for the treatment of sinusitis, allergic rhinitis, hives, allergic conjunctivitis and other associated allergic diseases.

List of common Antihistamines

Antihistamines are used to either treat allergy symptoms or digestive conditions (H1 or H2 blockers) by inhibiting histamine. What are some common antihistamine drugs? A list of common allergy medication examples include:

First-Generation Antihistamines

First-generation H1 Blockers are anti-allergy medicines that reduce the symptoms such as sneezing, itching, and runny nose. However, they come with a number of stronger side effects like drowsiness. - Diphenhydramine (DiphyCare™) - Chlorphenamine (ChlomaCare™) - Cyproheptadine (CyproCare™) - Clemastine - Promethazine (ProzinCare™) - Hydroxyzine - Azatadine - Doxylamine - Triprolidine - Betamethasone + Dexchlorpheniramine (BephenCare™)

Second-Generation Antihistamines

Second-generation antihistamines are also used to treat allergic reactions and ease the accompanying symptoms. They have fewer side effects than first-generation antihistamine medicines. - Cetirizine (CetriCare™) - Loratadine (LoraCare™) - Levocetirizine (LevinCare™) - Fexofenadine - Desloratadine (DesloCare™) - Azelastine (AzelCare™) - Ebastine - Bilastine - Rupatadine - Mizolastine

Why are we a top Antihistamines manufacturer?

For 20 years AdvaCare Pharma has manufactured and distributed a product range of more than 4,000 pharmaceuticals, medical devices, dietary supplements, and veterinary products in over 65 markets globally. A wide range of 500+ pharmaceutical products, available in 13 dosage forms, allows our distribution to remain sustainable and affordable. AdvaCare Pharma, a manufacturer of Antihistamines, offers an expansive range of cost-effective anti-allergy medicines available in various dosage forms.

AdvaCare Pharma has manufacturing facilities in China, India and the USA. Our production lines adhere to the highest international standards and with frequent facility inspections, these standards are guaranteed. We strictly comply with GMP rules and regulations, as well as ISO standards.