Diphenhydramine HCL Oral Solution (1 bottle)
Diphenhydramine HCL Oral Solution (1 bottle)
*Packaging color and/or animals may vary according to distribution region.

Diphenhydramine HCL Oral Solution

Diphenhydramine HCL Oral Solution is an antihistamine used for veterinary use. AdvaCare Pharma's manufacturing facilities are strategically located to enable the efficient production and distribution of veterinary products to customers worldwide.



What is Diphenhydramine HCL Oral Solution?

Therapeutic Class:
Target Species:

Active Ingredients: Diphenhydramine HCL

Diphenhydramine HCL Oral Solution is an antihistamine drug used to treat acute inflammatory and allergic conditions in poultry, sheep, horses, cows and dogs. It can be used to treat hives or itching or in the treatment of insect or snake bites. This drug is sometimes used for its sedative properties.

Diphenhydramine is an antihistamine or an H1 blocker. It works by inhibiting the action of histamine at the H1 receptor.

It is important to note that this formulation of AdvaCare's Diphenhydramine HCL Oral Solution is for veterinary purposes only.

AdvaCare Pharma is a global supplier of Diphenhydramine HCL Oral Solution. AdvaCare excels at the production of high-quality yet cost-effective treatments. This medication has been manufactured in our GMP-certified facilities located in China, India, and the USA.

Why are we a quality Diphenhydramine manufacturer?

AdvaCare Pharma, an American company, is a quality manufacturer of Diphenhydramine for veterinary use. We are committed to the manufacture and global distribution of over 250 GMP-certified veterinary medicines, including 70+ oral liquid formulations.

Our approach to supply chain management is systematic and data-driven, backed by a highly proficient team. We provide unparalleled support to our veterinary distributors throughout our partnership - assisting with supply chain coordination, document and product registration support, and market share growth.


What is Diphenhydramine HCL used for?

It's used to treat inflammatory and allergic conditions, such as

  • allergies, hives, eczema
  • coughing
  • sudden shock or laminitis
  • dyspnea

It is also used to reduce travel anxiety and motion sickness.

What animals can be treated with Diphenhydramine HCL Oral Solution?

It's recommended for cows, dogs, horses, poultry, and sheep. It should be noted that the oral formulation of Diphenhydramine is more suitable for monogastric animals than ruminants.

How is a Diphenhydramine HCL Oral Solution used?

This medication has been manufactured as a liquid, which is packaged in a bottle. It is intended for oral administration.

How should Diphenhydramine HCL Oral Solution be stored?

This medication should be stored in a dark, dry location between 20-25°C. The vial should be sealed tightly.

What is the withdrawal period for Diphenhydramine HCL?

The withdrawal time for this medicine is at least 7 days after the final treatment. For cattle or sheep, there have been some recorded withdrawal periods of ups to 28 days, so the exact duration will depend on local regulations.


How much Diphenhydramine Oral Solution should be given to livestock animals?

The usual dose is 1ml per 10kg of body weight.

How much Diphenhydramine Oral Solution should be given to horses?

The usual dose is 2-4mg per kg of body weight, given twice per day.

Side Effects

As with all pharmaceuticals, some unwanted effects can occur from the use of Diphenhydramine HCL Oral Solution.

Some reported side effects are as follows:

  • lethargy or sedation
  • dry mouth
  • urinary retention
  • gastrointestinal effects in cats
  • excitability, loss of appetite, tremors at high doses

For a comprehensive list of all possible side effects of this medication, consult a veterinary physician


Do NOT use Diphenhydramine HCL Oral Solution for an animal that:

  • has a known allergy or hypersensitivity to any of the ingredients.
  • is a very young or neonate.

Treatment with this drug should be administered with caution if an animal:

  • has conditions such as glaucoma, prostate enlargement, intestinal obstruction, heart disease, or hypertension.
  • has elevated thyroid hormones.
  • has a respiratory problem.
  • is pregnant or lactating.
  • is a working dog.
  • is geriatric.

There are known interactions between Diphenhydramine and other drugs, including anticholinergic drugs, tricyclic antidepressants, and CNS depressants.

This medicine can affect the results of a skin allergy test. Treatment should stop at least 2 weeks prior to this kind of test.

As ruminants have a low oral absorption efficiency of this medicine, it is not recommended to treat them with the Oral Solution.

*Regulatory compliance may vary according to production standard, import requirements and/or manufacturing origin.

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