Alpha-fetoprotein (AFP) is generated by the Alpha-fetoprotein gene. AFP (Alpha-Fetoprotein) is a single-chain glycoprotein with a molecular mass of 65 000 unified atomic mass. AFP is thought to transport polyunsaturated fatty acids to develop malignant cells because of its high affinity to these substances. In the chromosomal location 4q25 is the human AFP gene. Large promoter P1 and 3 enhancers control the expression of AFP.
AFP is produced in a developing fetus’s liver which travels through the placenta into the mother’s blood. AFP production ends between and twelfth week of gestation. During the second trimester of pregnancy, it is possible to measure the level of AFP in a pregnant woman. Unusual alpha-fetoprotein levels can be a sign of a birth defect or other conditions. These include a neural tube defect, Down syndrome, twins or multiple births, miscalculation of the due date or intellectual development. In theory, AFP is a fetal form of serum albumin in monomeric, dimeric and trimeric forms, which attaches to nickel, fatty acids, bilirubin, and copper. AFP (Alpha-Fetoprotein) function is not clear and it is still under investigation.
AFP blood test checks the risk of birth defects and genetic disorders. The AFP test is recommended if the pregnant woman is at least 35 years old, has diabetes or a family history of birth defects.
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- This is a newer rapid, sensitive, and specific technology;
- This technology is portable, automatic, and easily disposable;
- The sensitivity and specificity are fully validated and currently fulfill the basic requirements of rapid diagnostic tests;
- They are available, affordable, and usable as a point of care tests.
Store test kit in a sealed pouch in a refrigerator or at room temperature 2-30°C. Test Kit is usable before the expiration date.
Allow the test kit to reach room temperature (15-30°C) prior to testing. Remove the test cassette or strip from the sealed pouch and use it within 1 hour.
Accurate test results appear in 10 minutes. The AFP (Alpha-Fetoprotein) Test Kit is 99.0% accurate.
- This kit is designed for in vitro use only. Eating, drinking, or smoking in the area where the specimens or kits are handled is not advisable;
- Standard precautions for handling infectious agents should be observed when using this kit;
- Wear standard protective clothing such as a lab coat and disposable gloves when handling specimens and assay reagents in accordance with local regulations;
- Wash hands thoroughly after use;
- Reliable and inexpensive;