AdvaCare is a GMP manufacturer of Bromelain softgels.
Bromelain is an enzyme that is extracted from the stem and fruit of the pineapple that can help support healthy digestion and benefit the immune system. The term “bromelain” may refer to either of two protease enzymes extracted from the plants of the family Bromeliaceae, or it may refer to a combination of those enzymes along with other compounds produced in an extract.
Although tested in a variety of folk medicine and research models for its possible efficacy against diseases, the only approved clinical application for bromelain was issued in 2012 by the European Medicines Agency for a topical medication called NexoBrid used to remove dead tissue in severe skin burns.
Produced mainly in parts of the world where pineapples are grown, such as Thailand or Malaysia, bromelain is extracted from the peel, stem, leaves or waste of the pineapple plant after processing the fruit for juice or other purposes. The starting material is blended and pressed through a filter to obtain a supernatant liquid containing the soluble bromelain enzyme.
Further processing includes purification and concentration of the enzyme. At the optimum temperature, the enzyme acts the fastest, but (at least the fruit variant) is destroyed within a few minutes. After an hour at 50 °C (122 °F), 83% of the enzyme remains, while at 40 °C (104 °F), practically 100% remains. As a result of this, the optimum temperature for maximum cumulated activity over time is 35-45 °C.
When Bromelain is in the stomach, it will help the body break down and digest protein. Supplementation of bromelain can also reduce nasal inflammation, meaning it acts as a decongestant. If taken between meals, bromelain can benefit the immune.
Bromelains effects on fat cells are also under investigation, with promising preliminary evidence. Bromelains anti-inflammatory properties are responsible for several of its effects, including its ability to decongest the nasal cavity. Further research is needed to determine the mechanism through which bromelain survives the digestive system.