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      *AdvaCare Nikethamide Injection is GMP certified.

      **AdvaCare Nikethamide Injection is manufactured in our facilities located in China/India/USA.

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      *or according to distributor/market composition

      10 ampoules/box;100 ampoules/box

      *or according to distributor/market requirements


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        Product Information

        General Information:
        AdvaCare is a GMP manufacturer of Nikethamide injection.

        Nikethamide Injection is a respiratory stimulant used to treat respiratory depression due to chronic bronchitis. Nikethamide can also be used to treat overdoses of tranquilizers, sedatives, and barbiturates before endotracheal intubation and lung expansion. It is also commonly used as central stimulants and to treat hypotensive disorders.

        Nikethamide is also known as nicotinic acid diethylamide and its actions are similar to doxapram. Though, the respiratory stimulant dose is lower than the convulsant dose in conscious human individuals. In South America and Europe, it is commonly available in lozenge form as a short-acting over-the-counter drug to increase endurance in high altitudes. It also directly affects the heart by promoting the coronary flow in myocardial infection.

        Nikethamide works by acting directly on the brain’s respiratory centers. It is given as an injection into the vein by a healthcare professional in a hospital or clinic setting. Each mL of solution contains 250 mg of nikethamide.

        Side Effects:
        As with all pharmaceuticals, some unwanted effects can occur from the use of nikethamide. Always consult a doctor or health care professional for medical advice before use. Common side effects include, but may not be limited to swelling near the injection site, headache, dizziness, confusion, vomiting, and nausea. Seek medical attention if the following develop: allergic reaction, seizures, itching, breathing problems, hives, convulsions, breathlessness, or paresthesias.

        For a comprehensive list of all possible effects, consult your doctor.

        If any symptom persists or gets worse, or you notice any other symptom, please call your doctor immediately.

        Additional Information

        Always consult your doctor or pharmacist before administering nikethamide.

        If your condition does not improve or becomes worse, then call your doctor.

        Driving or operating machinery is okay as it does not cause dizziness or drowsiness.

        Do NOT use nikethamide if:

        • You are allergic to nikethamide or other containing ingredients;
        • You have porphyria;
        • You have hypertension, cardiovascular disease, or epilepsy.

        There is little evidence with regards to the use of nikethamide during pregnancy or breast feeding, so consult your doctor or health care professional before administering nikethamide.

        Refer to your doctor or pharmacist for guidelines on dosage. Do not exceed what they advise. Usual dose for adults is: 1 to 1.5g IV as needed.

        Nikethamide should be used with caution as it can be toxic in higher doses. It has been associated with acute porphyria attacks and should not be used in patients with porphyria. It has possible interactions with other drugs, medications, and supplements. This medication should be used with caution when using other stimulants or depressants. Consult with your doctor about any medications you are taking any medical conditions you have before a treatment with nikethamide.

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