Manufacturer of Antimalarials

Antimalarials prevent and treat malaria, a potentially life-threatening parasitic disease caused by plasmodium parasites transmitted through the bite of infected mosquitoes. Antimalarial drugs target various stages of the plasmodium parasite life cycle or reduce the number of parasites in the blood.

The effectiveness of malaria treatments varies depending on the specific drug and the type of plasmodium causing the infection. However, they have been shown to significantly reduce the risk of contracting malaria and improve survival rates in individuals with severe or complicated cases.

Antimalarial medications are mainly used in endemic areas of Africa, Asia, and South America where malaria is prevalent, and by travelers to these regions to prevent infection. Additionally, some antimalarial medicines may have other uses, such as treating certain autoimmune diseases.

Antimalarials are mainly used to treat and prevent malaria, a life-threatening disease that is caused by a parasitic infection transmitted by mosquitoes. The indications for malaria drug treatments include:

• Prevention of malaria
• Treatment of uncomplicated malaria
• Treatment of severe malaria
• Prophylaxis for individuals who are at high risk of developing malaria, such as pregnant women or individuals with HIV/AIDS
• Treatment of other diseases such as lupus and rheumatoid arthritis, as some antimalarial treatments have anti-inflammatory effects and can be used as disease-modifying agents

Antimalarial medications work by targeting the plasmodium parasites that cause malaria. They can prevent the parasites from entering and multiplying within red blood cells, or kill the parasites already present in the bloodstream. The exact mechanism of action depends on which antimalarial medicine is used.

Chloroquine and hydroxychloroquine are common examples that inhibit the parasite's ability to break down hemoglobin, while malaria medicines with artemisinin derivatives interfere with the parasite's ability to produce energy.

Antimalarials are used in the treatment of malaria. Although malaria medicines have one main indication, antimalarials can be divided into a number of drug types.

Aminoquinolines are a group of antimalarial medications that are derived from quinine, a natural substance found in the bark of the Cinchona tree. They work by interfering with the parasite's ability to break down hemoglobin, a protein found in red blood cells, thereby preventing the parasite from obtaining the nutrients it needs to survive. Aminoquinolines, such as chloroquine and hydroxychloroquine, are primarily used to treat uncomplicated malaria caused by Plasmodium species, such as Plasmodium falciparum and Plasmodium vivax.

Diaminopyrimidines are a group of antimalarial medicines that target the asexual erythrocytic phase of the malaria parasite. They inhibit the dihydrofolate reductase enzyme, which is essential for the production of nucleic acids, leading to the disruption of the parasite's DNA synthesis, and killing the parasite.

The main indication for diaminopyrimidines is the treatment of malaria caused by Plasmodium falciparum and other species. They are often used in combination with other malaria medicine to prevent the development of drug-resistant strains. Diaminopyrimidines are also used as prophylactic agents to prevent malaria.

Artemisinin and its derivatives, such as artemether and artesunate, are antimalarial drugs formulated from the plant Artemisia annua. They are used in the treatment of malaria, particularly for uncomplicated cases caused by Plasmodium falciparum. The mechanism of artemisinin and its derivatives involves the generation of reactive oxygen species within the malaria-infected red blood cells. This damages and destroys the parasites, including their ring-stage and mature forms (trophozoites and schizonts).

Artemisinin-based combination therapies, which combine artemisinin or its derivatives with other malaria medications, are commonly used to treat for uncomplicated P. falciparum malaria in many regions where the parasite has developed resistance to other antimalarial drugs. The combination with other antimalarials helps to enhance the effectiveness of treatment, reduce the likelihood of resistance, and ensure complete eradication of the parasite.

Antimalarials are used in the prevention and treatment of malaria. There are a number of methods for destroying parasitic infection, and therefore a wide range of types of malaria drug treatments are available. A list of common malaria medication examples include: - Hydroxychloroquine - Atovaquone - Mefloquine (MefloCare™) - Artesunate (ArsunCare™) - Chloroquine phosphate (ChloquinCare™) - Proguanil - Artemether + Lumefantrine (ArtelCare™) - Dihydroartemisinin (CotexCare™) - Primaquine phosphate (PriquinCare™) - Artemether (ArteCare™) - Quinine dihydrochloride (QuinCare™)

For 20 years AdvaCare Pharma has manufactured and distributed a product range of more than 4,000 pharmaceuticals, medical devices, dietary supplements, and veterinary products in over 65 markets globally. A wide range of 500+ pharmaceutical products, available in 13 dosage forms, allows our distribution to remain sustainable and affordable. AdvaCare Pharma, a manufacturer of Antimalarials, offers an expansive range of cost-effective treatments for malaria available in various dosage forms.

AdvaCare Pharma has manufacturing facilities in China, India and the USA. Our production lines adhere to the highest international standards and with frequent facility inspections, these standards are guaranteed. We strictly comply with GMP rules and regulations, as well as ISO standards.