Diphenhydramine HCL Injection (box of 1 vial)
Diphenhydramine HCL Injection (box of 1 vial)
*Packaging color and/or animals may vary according to distribution region.

Diphenhydramine HCL Injection

Diphenhydramine HCL Injection is an antihistamine for parenteral use. This injection has been manufactured by AdvaCare Pharma, a global manufacturer and supplier of GMP/ISO-certified veterinary products.



What is Diphenhydramine HCL?

Therapeutic Class:
Target Species:

Active Ingredients: Diphenhydramine HCL

Diphenhydramine HCL Injection is an antihistamine drug used for acute inflammatory and allergic conditions in animals like cows, horses, dogs and cats. It may be used to treat life-threatening allergic reactions, such as anaphylaxis, along with Epinephrine (Adrenaline). Diphenhydramine is also prescribed to treat canine motion sickness.

Diphenhydramine belongs to the family of medicines called antihistamines. It works by inhibiting the action of histamine at the H1 receptor.

It is important to note that this formulation of AdvaCare's Diphenhydramine Injection is for veterinary purposes only, and whilst there are types available for human use, this injection is intended to be prescribed by a veterinary doctor or animal care specialist for an animal.

AdvaCare manufactures this veterinary medicine in GMP-certified factories located in China, India, and the USA. We offer a broad range of high-quality veterinary medications available for distribution.

Why are we a trusted Diphenhydramine manufacturer?

Diphenhydramine Injection is manufactured and globally distributed by AdvaCare Pharma, a leading manufacturer of veterinary injections in the pharmaceutical industry. We have been committed to distributing high-quality, GMP-certified veterinary medications for the global market for the past 20 years. To ensure that our products meet and surpass our distributors' requirements, we carry out routine internal and third-party facility audits.


What is Diphenhydramine HCL used for?

It's used to treat inflammatory and allergic conditions, such as

  • allergies or hypersensitivity responses
  • inflammatory disease
  • allergies due to feed or other medicines
  • anaphylactic shock
  • sudden shock or laminitis in ruminants
  • aseptic total
  • emphysema (in horses)
  • asthma
  • insect or snake bites

It is also used as a mild sedative or to treat motion sickness.

What animals can be treated with Diphenhydramine HCL Injection?

It's recommended for cows, horses, and companion animals like dogs and cats.

How is a Diphenhydramine HCL Injection used?

This medication has been manufactured as a liquid, which is packaged in a vial. It is intended to be administered by injection in the vein, muscle, or under the skin. Diphenhydramine HCL Injection is intended for veterinary use only.

How should Diphenhydramine HCL Injection be stored?

This medication should be stored in a dark, dry location between 20-25°C. The vial should be sealed tightly.

What is the withdrawal period for Diphenhydramine HCL?

The withdrawal time for this medicine is 1-7 days after the final treatment. For milk, the withdrawal period is 1-3 days.


How much Diphenhydramine Injection should be given to ruminants?

For large ruminants, the usual dose is 1-2mg per kg of body weight.

How much Diphenhydramine Injection should be given to dogs or cats?

The usual dose is 2-4mg/kg, given 2-3 times per day. This medicine may not be appropriate for kittens or small cats.

Side Effects

As with all pharmaceuticals, some unwanted effects can occur from the use of Diphenhydramine HCL Injection.

Some common side effects may include but are not limited to:

  • lethargy
  • dry mouth
  • urinary retention
  • gastrointestinal effects in cats

Serious side effects may include: • severe allergic reaction (skin rash, fever, facial swelling, or difficulty breathing)

For a comprehensive list of all possible side effects of this medication, consult a veterinary physician.


Do NOT use Diphenhydramine HCL Injection for an animal that:

  • has a known allergy or hypersensitivity to any of the ingredients.
  • is a very young or a neonate.

Treatment with this drug should be administered with caution if an animal:

  • has conditions such as glaucoma, prostate enlargement, intestinal obstruction, COPD, heart disease, or hypertension.
  • has elevated thyroid hormones.
  • is pregnant or lactating,
  • is a working dog.
  • is geriatric.

There are known interactions between Diphenhydramine and other drugs, including anticholinergic drugs, tricyclic antidepressants, and CNS depressants.

This medicine can affect the results of a skin allergy test. Treatment should stop at least 2 weeks prior to this kind of test.

*Regulatory compliance may vary according to production standard, import requirements and/or manufacturing origin.

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