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Always consult a veterinary physician or animal care specialist before using Diphenhydramine Hydrochloride Injection.
Indications and Usage
Diphenhydramine is used in the treatment of allergies in dogs. It belongs to the class of antihistamines which may also be used as an antiemetic and is used to prevent motion sickness in dogs. Antihistamines alone can control pruritis in 20-40% of atopic dogs.
It has H1 receptors which play a role in the emetic response associated with motion sickness in dogs (but not in cats). Diphenhydramine will cause some central nervous system (CNS) depression and sedation, although the sedative effects may diminish with time.
Diphenhydramine also is used to treat neurotoxicity or extrapyramidal effects due to phenothiazines, metoclopramide, and tremors due to organophosphate or carbamate poisoning.
Administration and Dosage
Administration of diphenhydramine hydrochloride in livestock is not advisable.
Usual dosage is as follows: 1-2 mg of diphenhydramine per kg body weight (intravenously, intramuscularly and subcutaneously) in dogs and cats. Diphenhydramine injections shouldn’t be administered if any hypersensitivity is discovered.
Refer to an animal care specialist for guidelines on dosage. Do not exceed what they advise, and complete the full treatment, as stopping early can result in a recurrence or worsening of the problem.
Completion of full treatment is always advisable with or without the presence of symptoms.
- The dose of diphenhydramine should be adjusted cording to the need of an individual animal because every animal may have different response towards antihistamines;
- Antihistamines should be used with caution in working dogs due to its tranquilizing side effects;
- Diphenhydramine should be used with caution in animals with prostatic hypertrophy, bladder neck obstruction, severe heart failure, angle closure glaucoma, pyeloduodenal obstruction, hyperthyroidism, seizure disorders and hypertension or allergic lung disease (COPD) ;
- Older animals are more sensitive to side effects from antihistamines. A lower dose of diphenhydramine may be indicated in older animals.
High dosage of diphenhydramine can lead to birth defects in animals. Diphenhydramine is excreted in breast milk. It should not be used in pregnant or lactating animals.
Keep away from children. Diphenhydramine should not be used with additional tranquilizing medications.
Overdose with diphenhydramine can cause symptoms ranging from CNS stimulation to CNS depression.
Symptoms of overdose range from mild sedation and clumsiness to severe seizures, respiratory depression, coma ultimately death can occur after a massive overdose.
Diphenhydramine may have a tranquilizing effect when combined with other CNS depressant drugs, such as barbiturates and tranquilizers or when combined with other anticholinergic agents. Diphenhydramine may interfere with neurotransmitters. It may decrease the effects of heparin and warfarin.
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