Always consult a veterinary physician or animal care specialist before using tylosin injections.
Indications and Usage
Tylosin Injection is indicated in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Actinomyces pyogenes; foot rot and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Actinomyces pyogenes in beef cattle and nonlactating dairy cattle.
In swine, tylosin is indicated in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae; acute swine dysentery associated with Treponema hyodysenteriae.
Tylosin is contraindicated in animals allergic to other macrolide antibiotics (e.g., erythromycin). Some studies have shown that tylosin is contraindicated in horses, which may result in severe and fatal diarrheas whenever used in these species.
Administration and Dosage
For intramuscular injection only.
Usual dosage is as follows: 8mg of tylosin per 0.45kg body weight in cattle once daily (1 mL of the 200 mg per 25 pounds). Swine – 4mg per 0.45 kg per body weight (1 mL of the 200 mg per 50 pounds). Tylosin injections shouldn’t be administered if any hypersensitivity is discovered.
Treatment should be continued 24 hours or when the patient is asymptomatic. Treatment should not be exceeded more than 5 days. Administration of dosage more than 10 ml in cattle and more 5ml in swine per site is not recommended.
Refer to an animal care specialist for guidelines on dosage. Do not exceed what they advise, and complete the full treatment, as stopping early can result in a recurrence or worsening of the problem.
Adverse reactions, including shock and death may result from over dosage in baby pigs. Administration of dosage more than 0.5ml into pigs weighing less than 25 pounds is not advisable.
Discontinuation of the therapy in cattle 21 days before slaughter is recommended. In swine, discontinue the therapy 14 days prior to slaughter. Use of therapy in lactating dairy cattle is not recommended.
A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.
Tylosin is relatively safe in most overdose situations. Shock and death have been reported in baby pigs overdosed with tylosin.
Studies have shown that, tylosin may increase digoxin blood levels with resultant toxicity. It is recommended for an erythromycin monograph reference for more information on potential interactions.