AdvaCare is a GMP manufacturer of Vitamin K2 softgels.
Vitamin K2 is one group of vitamin K, the other being vitamin K1. K2 is rare and has not received much attention for its benefits. It was discovered at the beginning of the 20th century as essential for preventing blood clotting and maintaining oral health. Vitamin K2 is a group of compounds mainly derived from meats, cheese, and eggs. They are synthesized by bacteria. While vitamin K1 is typically found in plant foods, K2 is found in animal and fermented foods.
Vitamin K2 helps regulate where calcium goes into the body by activating proteins. Calcium is critical for joint health (building bones and teeth) and other biological processes. Since calcium can build up around the heart and increase the risk for heart disease, vitamin K2 helps prevent heart disease by preventing the calcium from being deposited in the heart arteries.
Those with less calcium in their bones have been known to have an excess of calcium in their arteries, showing the importance of K2 in mobilizing calcium. K2 has also been used to treat osteoporosis and steroid-induced bone loss. Vitamin K2 helps matrix Gla protein and osteocalcin, two proteins, calcium-bound together to build and maintain bones. Likewise, since K2 activates the same protein osteocalcin, it stimulates the growth of teeth. Vitamin A and D are believed to work with K2 to improve dental health in this way. Vitamin K2 has been correlated with improved survival rates for liver cancer patients and a lower risk of advanced prostate cancer.
K2 is produced by gut bacteria in the large intestine. The body can convert K1 into K2, but would be much more efficient to consume K2 directly, especially since the amount of vitamin K1 in a diet is typically 10 times that of K2; the consumption of K2 in the modern diet is very low. Since Vitamin K is fat soluble, it is low fat and lean animal products have low amounts of it. Taking Vitamin K supplements with vitamin D supplements may benefit because they have synergistic effects.
Take vitamin K2 supplements in moderation; most people including pregnant and breastfeeding women and children do not experience side effects when taking the daily recommended amount. Do not take high doses if you have a severe liver or kidney disease. Monitor your blood sugar closely if you are diabetic.