Norfloxacin Tablets

Active Ingredients: Norfloxacin

Norfloxacin Tablets are an antibiotic drug used to treat uncomplicated and complicated bacterial infections. It is indicated for the treatment of upper and lower urinary tract infections including cystitis, pyelitis, cystopyelitis, pyelonephritis, some sexually transmitted diseases, and urethral and cervical gonorrhea.

Norfloxacin is classified as a quinolone antibiotic. It works by stopping the growth of bacteria. Norfloxacin shows broad-spectrum action against gram-positive and gram-negative bacteria.

AdvaCare Pharma is a trusted global exporter of Norfloxacin Tablets. This medication is produced in our facilities in China, India, and the USA. Our manufacturing facilities are GMP certified and are regularly inspected in order to ensure they meet health, safety, and environmental standards.

AdvaCare Pharma is a trusted Norfloxacin manufacturer committed to providing quality-assured, cost-effective pharmaceuticals for an ever-changing global market. Manufacturing a wide range of 200+ pharmaceutical products in tablet form, we ensure that all of our oral solid dosage forms adhere to stringent GMP standards.

We operate according to a unique "vested supplier-distributor relationship" business model, in which we tie our success in a market to that of our distributor. Such a model facilitates a closer relationship by working together to achieve pre-defined goals for market entry and expansion. As a Norfloxacin manufacturer and global supplier, we implement unique strategies to ensure successful distribution.

What is Norfloxacin used for?

How should Norfloxacin Tablets be used?

This medication is intended to be taken orally. The tablets should be taken with a glass of water. Norfloxacin Tablets should be taken at least 1 hour before or 2 hours after food, milk, or dairy products. It is also important to take them at least 2 hours before or 2 hours after any product containing iron, zinc, aluminum, or magnesium, such as antacids, mineral supplements, or multivitamins.

What dose should be taken?

Recommended dosage of Norfloxacin may vary based on different medical conditions and age.

The exact dosage is based on medical condition, response to treatment, age, and weight. Refer to a doctor or pharmacist for guidelines on dosage. Do not exceed what they advise.

Renal Dosing For patients with CrCl < 30, the adjusted dose for UTIs is 400mg taken once a day. Guidelines have not been defined for other types of infections.

Hepatic Dosing Dosing adjustment guidelines have not been defined for patients with hepatic impairment.

Who can use Norfloxacin?

Norfloxacin Tablets can be given to adults and children, but caution is advised for specific groups of patients.

Pregnant This medication is not recommended for use by pregnant women and is contraindicated in some regions. Norfloxacin should only be used if the benefits outweigh the risks. Animal studies have shown the potential for possible fetal harm, but limited human data has not shown any increase in harmful effects.

Breastfeeding This medicine should only be used if the benefits outweigh the risks. Its use is contraindicated by some authorities. If there is a clear need for the drug, it is advised to wait 24-48 hours to breastfeed. A low amount of Norfloxacin is passed in milk. It is important to monitor for gastrointestinal problems in the infant, such as diarrhea or candidiasis.

Children The safety and efficacy of this medication have not been established for pediatric patients younger than 18 years old.

Geriatric Norfloxacin can be used for elderly patients with no special consideration. It is important to note that renal impairment is more prevalent among this population, so adjustments may be necessary for some older patients.

How should Norfloxacin Tablets be stored?

It is recommended to keep the tablets in their original packaging until use. The medicines should be in a location that is 25°C. The drug can withstand short excursions to 15-20°C, but it should be protected from any extreme heat or cold.

Other warnings

Fluoroquinolones have been associated with severe and potentially irreversible adverse effects, such as tendinitis, tendon rupture, peripheral neuropathy, and central nervous system (CNS) effects.

The increased risk of tendinitis and tendon rupture affects all ages but is further increased for patients who are older than 60 years old, also taking corticosteroids, or those who have had a liver, heart, or lung transplant. Additional increased risk factors include excessive physical activity, renal failure, or tendon disorders like rheumatoid arthritis. It is important to note that this drug class has caused tendinitis and tendon rupture in patients without these risk factors.

Peripheral neuropathy has been reported by patients taking Norfloxacin or other fluoroquinolones. Symptoms typically occur shortly after starting treatment with this drug, and it is important to note that it may be irreversible in certain patients. For patients with a history of peripheral neuropathy, this drug should be avoided.

This drug should be used cautiously in patients who have a known or suspected CNS disorder, including cerebral arteriosclerosis, epilepsy, or a history of seizures.

Norfloxacin should be avoided for patients with a known history of myasthenia gravis, as deaths have been associated with this use of this medication.

As with all pharmaceuticals, some unwanted effects can occur from the use of Norfloxacin Tablets.

For a comprehensive understanding of all potential side effects, consult a medical professional.

If any symptoms persist or worsen, or you notice any other symptoms, please call your doctor immediately.

Due to possible drug interactions, consult with your doctor about any medications, supplements, or herbal products you are taking before your treatment. Norfloxacin is known to interact with drugs such as theophylline and diuretics. It is also known to interact with caffeine, multivitamins, and antacids. This is not a complete list.

Sun sensitivity may occur while taking this medicine. It is recommended to avoid sunlight or UV light exposure while undergoing treatment with norfloxacin.

Some people experience dizziness after taking norfloxacin. It is advised to avoid driving or operating machinery until the effects of the medication are clear.

It is recommended to avoid drinking alcohol. The combination of alcohol and norfloxacin may increase the severity of adverse effects.

This drug may interfere with certain live bacterial vaccines (e.g. typhoid vaccine). Consult a healthcare profession if you have an upcoming immunization or vaccination.

Review of the Efficacy of Oral Norfloxacin in Pyelonephritis and Nosocomial Urinary Tract Infection

This study included one hundred thirty-eight patients diagnosed with pyelonephritis who received treatment with norfloxacin at a dose of 400mg twice daily. Among them, women constituted 74% of the cases, with Escherichia coli being the most commonly isolated pathogen, accounting for 51% of the cases.

Antibody-coated bacteria (ACB) tests were conducted in 48% of the patients, and of those tested, 72% (48 out of 67) were found to be positive. Forty percent of the patients presented with temperatures exceeding 37.6 °C at the onset of the study. Cure rates among patients with both fever and positive ACB tests were comparable to those of afebrile patients who tested negative for ACB.

Norfloxacin had high effectiveness in treating multidrug-resistant, nosocomial urinary tract infections (UTIs), where Pseudomonas aeruginosa and E. coli were the predominant pathogens.

The conclusion of this study is that norfloxacin is a highly effective alternative therapy for certain UTIs.

Norfloxacin 400mg: Why the most common dosage?

Norfloxacin 400mg is the most favorable dose in treating urinary tract infections and certain types of gastroenteritis, providing a balance of efficacy and minimal side effects. This dose ensures adequate bacterial eradication with a convenient dosing schedule.