Methotrexate Tablets (box of 100 tablets)
Methotrexate Tablets (blister of 10 tablets)
Methotrexate Tablets (box of 100 tablets)
Methotrexate Tablets (blister of 10 tablets)
*Packaging color may differ according to distribution region.

Methotrexate Tablets

Methotrexate Tablets are an antimetabolite/antifolate medicine indicated for leukemia, cancer, and autoimmune diseases. AdvaCare Pharma manufactures this anti-cancer drug in its ISO and GMP-certified facilities.



What is Methotrexate?

Therapeutic Class:

Active Ingredients: Methotrexate

Methotrexate Tablets are used to treat leukemia and some types of cancer. It may also be prescribed for autoimmune diseases like severe psoriasis and rheumatoid arthritis. Methotrexate is also indicated for the treatment of active polyarticular-course juvenile rheumatoid arthritis in children over 2 years old.

Methotrexate is classified as an antimetabolite and antifolate, which works by interfering with the growth of certain cells of the body. It is particularly effective against cells that reproduce quickly, such as cancer, bone marrow, and skin cells. The active ingredient is also an immunosuppressant and therefore works to treat rheumatoid arthritis by decreasing immune system activity.

AdvaCare Pharma is a trusted global supplier of Methotrexate Tablets. Our company offers a wide range of high-quality and cost-effective medical products for distribution. Our factories are GMP-certified and regularly inspected to ensure they meet the high standards necessary to comply with WHO rules and regulations.

Why are we a trusted Methotrexate manufacturer?

AdvaCare Pharma manufactures a variety of oncology medications, including Methotrexate Tablets, at GMP-certified facilities. We are committed to producing cost-effective, high-quality cancer treatments that meet the highest industry standards and are readily available to cancer patients worldwide. Our global reach extends to over 65 markets, where we supply our products to distributors, hospitals, pharmacies, NGOs, and government institutions.


What is Methotrexate used for?

It's used to treat leukemia and some types of cancer of the breast, bones, skin, head, neck, or lungs. It's also used to treat rheumatoid arthritis or severe psoriasis. It's also used to treat idiopathic arthritis in children over 2 years old.

How are Methotrexate Tablets used?

This medication has been manufactured to be taken orally.

What dose should be taken?

The usual starting dose is 20mg/m², taken once a week.

As monotherapy for mycosis fungoides, the usual dose is 25-75mg, taken once per week. As a combination treatment, the dose is 10mg/m², taken twice per week.

For relapsed or refractory non-Hodgkin lymphoma, the usual dose is 2.5mg, taken 2-4 times per week as part of a multidrug chemotherapy treatment plan.

For rheumatoid arthritis or severe psoriasis, the usual dose is 7.5-25mg, taken once per week. Treatment is typically combined with folic acid or leucovorin.

For juvenile idiopathic arthritis in pediatric patients over 2 years old, the usual dose is 10-15mg/m², taken once per week. The maximum dosage is 25mg per week.

Side Effects

As with all pharmaceuticals, some unwanted effects can occur from the use of Methotrexate Tablets.

Some common side effects include, but may not be limited to:

  • blood in the urine
  • bloody vomit
  • reddening of the skin
  • stomach pain
  • sores in the mouth or lips

Seek medical attention if the following develop:

  • diarrhea
  • ulcerative stomatitis

For a comprehensive list of all possible effects, consult a doctor.

If any symptom persists or gets worse, or you notice any other symptoms, please call your doctor immediately.


Do NOT use Methotrexate Tablets if:

  • You are allergic or hypersensitive to any of the ingredients.
  • You are pregnant or breastfeeding.
  • You have rheumatoid arthritis with alcoholism, alcoholic liver disease, or any chronic liver disease.

This medication may not be suitable for people with certain conditions, including:

  • kidney disease
  • breathing problems
  • stomach ulcer
  • ulcerative colitis
  • any infection
  • any radiation treatment

Do not use Methotrexate to treat arthritis during pregnancy, as it can cause fetal death. The use of Methotrexate while breastfeeding can cause adverse reactions in babies. Consult a doctor or healthcare professional before beginning treatment.

It is possible for Methotrexate to affect fertility in both female and male patients. It is important to use birth control during treatment with this drug.

Many drugs are known to interact with Methotrexate, including antibiotics, sulfa drugs, folic acid, theophylline, or stomach acid reducers.

*Regulatory compliance may vary according to production standard, import requirements and/or manufacturing origin.

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Why AdvaCare Pharma?

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