Ivermectin Pour-On Solution
Dosage
Packaging
What is Ivermectin?
Active Ingredients: Ivermectin
Ivermectin Pour-On Solution is a dewormer drug used to treat parasites in horses and livestock animals such as camels, cows, goats, and sheep. It is used in the treatment of gastrointestinal roundworms, eyeworms, horn flies, lice, mites, and grubs. Depending on the infection, it may be necessary to combine this external treatment with an internal dewormer.
Ivermectin belongs to the family of medicines called anthelmintics. This compound has been derived from avermectin. Ivermectin works by inhibiting the function of aspects of the nervous system within the parasite. This leads to its paralysis and then the death of the parasite.
Known as a 'wonder drug' it originates from a single microorganism isolated from Japanese soil and finds extensive use in both human and animal applications. Ivermectin is renowned for its efficacy in eliminating a broad spectrum of internal and external parasites in commercial livestock and companion animals, with recent utilization in human medicine.
Its mechanism of action involves causing neurological damage to specific parasites, leading to paralysis and eventual death. Presently, the FDA approves Ivermectin for heartworm prevention in dogs and as a topical treatment for ear mites in canines. The absorption of Ivermectin is influenced by factors such as the route of administration, formulation, and the species of the animal. Once in the bloodstream, the drug binds to albumins and lipoproteins, distributing throughout the entire organism. While some of the drug accumulates, a portion undergoes biotransformation in the liver and fat. The drug's excretion is gradual, with approximately 2% eliminated through urine and over 90% through bile and feces.
The This drug is also available in the form of injection, premix, oral solution, and tablet. The treatment choice depends on the choice of the veterinarian and the current health condition of the animal.
It is important to note that Ivermectin Pour-On Solution is for veterinary purposes. This product is intended for external use only.
AdvaCare Pharma is a global distributor of Ivermectin Pour-On Solution. AdvaCare excels in producing high-quality yet cost-effective veterinary supplies and medicines. This product is manufactured in our GMP-certified facilities located in China, India, and the USA.
Why are we a quality Ivermectin manufacturer?
AdvaCare Pharma is a leading GMP-certified manufacturer of Ivermectin Pour-On Solution. We manufacture a wide range of over 250+ veterinary medicines, including 70+ liquid formulations, to meet the needs of veterinary distributors worldwide.. From supply chain coordination to document and registration support, we offer unbeatable assistance throughout the entire process.
Uses
What is Ivermectin used for?
It's used to treat certain infections, such as:_
- gastrointestinal roundworms, including Ostertagia ostertagi, Haemonchus placei, Trichostrongylus axei, Cooperia surnabada, Nematodirus helvetianus, Oesophagostomum radiatum, O. venulosum, Trichuris ovis, and Strongyloides papillosus
- eyeworms, including Thelazia gulosa and T. skrjabini
- mites, including Chorioptes bovis and Sarcoptes scabiei
- lungworms, including Dictyocaulus viviparus
- lice, including Linognathus vituli, Haematopinus eurysternus, Damalinia bovis
- cattle grubs
- horn flies
What animals can be treated with Ivermectin Pour-On?
This drug is recommended for horses, cows, camels, goats, and sheep.
How is Ivermectin Pour-On Solution used?
This medication has been manufactured as a liquid, which is intended to be administered topically. Ivermectin Pour-On Solution is intended for veterinary use only.
For total parasite control, it is recommended to use this drug alongside other anthelmintic treatments for certain parasitic infections. Be sure to use this treatment in a well-ventilated environment.
Why is Ivermectin Pour-On Solution used in animals?
Ivermectin is a GABA agonist and causes paralysis in susceptible arthropods and nematodes that cause serious infections in animals. It is an agonist for glutamate-gated chloride channels. Its administration can lead to fast recovery with good prognosis.
Why is Ivermectin Pour-On Solution used in companion animals?
In companion animals like dogs and cats, it is used for treating Sarcoptes scabiei, Otodectes cynotis, Cheyletiella blakei, C. yasguri, and Demodex canis. These ectoparasites are susceptible to this insecticide. For a full recovery, 3-4 medicated baths per week are recommended, depending on the cause of the disease.
What are the levels of absorption of Ivermectin in animals?
In dogs and horses, the absorption is similar, and it is much faster than in ruminants and pigs.
Why is Ivermectin Pour-On Solution used in ruminants?
In cattle, it is used for treating psoroptic mange, lice, and Hypoderma larvae.
Why is Ivermectin Pour-On Solution used in horses?
In horses, it is used for treating equine filarial dermatitis from Onchocerca cervicalis.
Why is Ivermectin Pour-On Solution used in pigs?
In pigs, it is used for treating Sarcoptes scabiei.
Can Ivermectin Pour-On Solution be used in humans?
Ivermectin is approved for treating certain infections by parasitic worms, head lice, and skin conditions. But FDA has not authorized or approved Ivermectin for the prevention and treatment of COVID-19 in humans.
How should Ivermectin Pour-On Solution be stored?
This medication should be stored in a dark, dry location under 25°C. The bottle should be sealed tightly during storage.
What is the withdrawal period for Ivermectin?
The withdrawal period is 28 days for meat. There has not been a milk withdrawal period established, except in certain geolocations. Do not use this Pour-On solution for pre-ruminant calves.
The exact duration will depend on local regulations.
Dosage
How much Ivermectin Pour-On Solution should be used on cattle?
The usual dose is 1ml per 10kg of body weight.
This medicine should be applied in a narrow strip along the dorsal top-line of the animal.
Refer to a veterinary doctor or pharmacist for guidelines on dosage.
Side Effects
As with all pharmaceuticals, some unwanted effects can occur from the use of Ivermectin Pour-On Solution.
Adverse reactions have not been well documented. Some serious side effects may include:_
- allergic reaction (skin rash, fever, facial swelling, or difficulty breathing)
In dogs with Demodex, be especially cautious because Ivermectin is not always recommended due to its ability to penetrate the blood-brain barrier and gene mutations might occur. Common symptoms associated with its use include central nervous system (CNS) depression, visual impairment, and ataxia. Side effects typically manifest when the dose is ten times higher than the prescribed amount.
Dog breeds most susceptible to gene mutations caused by Ivermectin include Shetland Sheepdogs, Collies, Old English Sheepdogs, Australian Shepherds, and other herding dogs. However, it's essential to note that side effects may not necessarily occur in these breeds. The decision to administer Ivermectin should be made by a veterinarian. Dogs with gene mutations producing P-glycoprotein may experience toxicosis even at therapeutic dosages for Demodicosis. Initial signs include mydriasis, ataxia, and tremors, progressing to collapse, coma, and respiratory failure at higher dosages.
For a comprehensive list of all possible side effects of this medication, consult a veterinarian.
Precautions
Do NOT use Ivermectin Pour-On Solution for an animal that:
- has a known allergy or hypersensitivity to any of the ingredients.
- is producing milk for human consumption.
- non-lactating dairy cows that are within 60 days of calving.
- has a known allergy or hypersensitivity to any of the ingredients.
- is a foal less than 4 months old or a puppy less than 6 weeks old.
- is a dairy animal within 28 days of calving.
- is of the following species: chelonian, Indigo snake, and skink
Wear protective gloves and clothing while handling this product, and thoroughly wash your hands after application.
Ivermectin is toxic to fish and other aquatic life. Do not use it in ponds or other bodies of water. Dispose of any waste material according to local regulations.
Administration of this drug requires caution when dealing with an animal: • prone to the ABCB1-1∆ (MDR1-allele) mutation. Collie-type breeds of dogs, in particular, should undergo at least 8 hours of observation post-treatment. While this drug interacts with their multi-drug resistance gene, not every Collie or herding dog possesses this mutation if this is indeed the intended meaning.
Common symptoms of ivermectin toxicity include neurological signs._Interactions are known to occur between this medication and other drugs, including benzodiazepines, ketamine, spinosad, amiodarone, carvedilol, clarithromycin, cyclosporine, and ketoconazole.
Be aware that this drug may cause false-negative results in animals with occult heartworm infections.
This product is exclusively intended for animal use and should be administered by a veterinarian or as per the provided instructions.
Adhere to the dosage prescribed by the veterinarian to prevent potential side effects of overdosing. If accidental overdosing occurs, it should be promptly addressed, with due attention to managing associated health issues.
Maintain good hygiene practices when administering this drug. If the skin is dirty, clean it before applying this medication.
In case of a missed dose, refrain from administering two doses.
What are the most common animals for which Ivermectin Pour-On Solution is used?
Ivermectin Pour-On Solution is primarily used to treat various parasitic infestations in animals and livestock. The specific animal species and common uses of Ivermectin Pour-On Solution can include:
- gastrointestinal roundworms
- eye worms
- horn flies
- lice
- mites
- grubs
Cattle External Parasites
Ivermectin Solution controls and prevents external parasites like mites, lice, and ticks in cattle, including:
- Hypoderma bovis
- Hypoderma bovis
- Psoroptes ovis
- Sarcoptes scabiei var. Bovis
- Solenopotes capillatus
- Haematopinus eurysternus
Swine (Pigs) External Parasites
Swine may suffer from external parasite infestations, and Ivermectin is used for management. Ivermectin is used for treating the following:
- Sarcoptes scabiei var. suis
- Haematopinus suis
Horses External Parasites
Ivermectin Solution for horses helps control external parasites, including mites, lice, and ticks. Ivermectin can improve the general health condition of an animal affected by external parasites.
Dogs and Cats External Parasites
Ivermectin is more commonly administered orally or as a topical spot-on for dogs and cats to control internal and external parasites. Consult with a veterinarian for guidance.
Veterinarians should decide whether the drug is appropriate for the animal’s current health condition. It is often combined with internal dewormers.
