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      *AdvaCare Benzathine Penicillin Powder for Injection is GMP certified.

      **AdvaCare Benzathine Penicillin Powder for Injection is manufactured in our facilities located in China/India/USA.

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      Active Ingredients:

      Benzathine Penicillin

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        Product Information

        General Information:
        AdvaCare is a GMP manufacturer Benzathine penicillin powder for injection.

        Benzathine benzylpenicillin, also known as benzathine penicillin, is a slow-onset antibiotic that fights bacteria in your body. It is used when low concentrations of benzylpenicillin are required for a longer period of time. Even after 2 weeks of administration of a single IM dose, the antibiotic remains very active. Benzathine penicillin powder for injections is used to treat many different types of severe infections, including strep infections, rheumatic fever, and syphilis.

        Side Effects:
        As with all pharmaceuticals, some unwanted effects can occur from the use of penicillin benzathine injection. Always consult a doctor or healthcare professional for medical advice before use.

        Common penicillin benzathine side effects can include nausea, vomiting, blurred vision, ringing in your ears, headache, dizziness, mild skin rash, or pain, swelling, bruising, skin changes, hives, difficulty breathing, swelling of your face, lips, tongue or throat, and a hard lump at the injection site

        For a comprehensive list of all possible effects of penicillin benzathine, consult your doctor. If any symptom persists or gets worse, or you notice any other symptom not listed, then please call your doctor immediately.

        Additional Information

        Always consult your doctor or pharmacist before taking benzathine penicillin powder for injection.

        Indications and Usage

        Penicillin benzathine is indicated for infections caused by wounds, pyogenic infections of the skin, soft tissue infections and infections of the nose, throat, nasal sinuses, respiratory tract, and middle ear.

        Penicillin benzathine is also indicated for generalised infections, septicaemia, pyaemia from susceptible bacteria, acute and chronic osteomyelitis, sub-acute bacterial endocarditis, and meningitis caused by susceptible organisms.

        Penicillin benzathine is also used in the treatment of suspected meningococcal disease, gas gangrene, tetanus, actinomycosis, anthrax, leptospirosis, rat-bite fever, listeriosis, severe Lyme disease, and prevention of neonatal group B streptococcal infections.

        Penicillin benzathine is also used to cure complications caused by gonorrhea, syphilis, diphtheria, brain abscesses, and pasteurellosis.


        Penicillin benzathine is contraindicated in the patients who are cross allergic to beta-lactams such as cephalosporins.


        Consult your doctor about any medications you are taking before you begin treatment with benzathine penicillin powder for injection.

        Do not use benzathine penicillin powder for injections if you:

        • Have a history of allergy/hypersensitivity towards antibiotic drugs or penicillin;
        • Have impaired renal function;
        • Have asthma, kidney problems, or liver problems;
        • Have diabetes;
        • Have pseudomemvranous colitis because it may lead to severe diarrhea.

        There is little evidence surrounding the use of benzathine penicillin powder for injections during pregnancy or breast feeding, so consult your doctor or health care professional before using aminophylline. Theophylline can be excreted into breast milk, but it is unlikely to cause serious adverse reactions.

        Administration and Dosage

        The usual dose for adults is 1 to 6mega units daily divided into 4 to 6 doses, depending on the indication. Higher doses up to 24mega units in divided doses may be prescribed in the case of serious infections such as adult meningitis by the intravenous route.

        The usual dose for children (1 month to 12 years) is 100mg/kg/day in 4 divided doses, not exceeding 4g/day. The usual dose for infants (1-4 weeks) is 75mg/kg/day in 3 divided doses.

        Refer to your doctor or pharmacist for guidelines on dosage. Do not exceed what they advise.


        Benzathine penicillin may interact with other drugs such as probenecid (benemid), blood thinner such as warfarin, Methotrexate (Rheumatrex, Trexall), tetracycline antibiotics such as doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).


        Symptoms of overdose include trouble breathing and passing out. These symptoms should be reported to a medical professional. If you experience any of these symptoms, seek medical help immediately.

        Adverse Reactions

        An allergic reaction to penicillin may occur. A transient local reaction may occur in the place of application.

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