*AdvaCare Tilmicosin Injections is GMP certified.

**AdvaCare Tilmicosin Injections is manufactured in our facilities located in China, India and USA.

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Product Information

General Information:
AdvaCare is a GMP manufacturer of Tilmicosin injections.

Tilmicosin injection is a semi-synthetic broad-spectrum macrolide antibiotic synthesized from tylosin. It has an antibacterial spectrum that is predominantly effective against Mycoplasma, Pasteurella, and Haemophilus spp. and various Gram-positive organisms such as Staphylococcus spp. It is believed to affect bacterial protein synthesis.

Tilmicosin is used in the treatment for respiratory infections in cattle and sheep associated with Mannheimia haemolytica, Pasteurella spp. and other tilmicosin-susceptible micro-organisms, and for the treatment of ovine mastitis associated with Staphylococcus aureus and Mycoplasma spp.

Additionally, it is recommended to use in the treatment of interdigital necrobacillosis in cattle (bovine pododermatitis, foul in the foot) and ovine foot rot.

Tilmicosin is excreted mainly via the bile into the feces, with a small proportion being excreted via the urine.

Side Effects:
As with all veterinary medicine, some unwanted effects can occur from the use of tilmicosin injections. Always consult a veterinary physician or animal care specialist for medical advice before use.

Common side effects include: ataxia, lethargy and drooping of the head. Rarely, a transient reaction along with swelling may occur at the injection site which recedes without further treatment.

If you notice any serious effects or other effects not mentioned on this package, please inform your veterinary surgeon.

For a comprehensive list of all possible effects, consult a veterinary physician. If any symptom persists or gets worse, or you notice any other symptom, then please seek veterinary medical treatment immediately.

Additional Information

Always consult a veterinary physician or animal care specialist before using tilmicosin injections.

Indications and Usage

Cattle. It is indicated in the reatment of bovine respiratory disease associated with Mannheimia haemolytica, and Pasteurella multocida. It is also used in the treatment of interdigital necrobacillosis (bovine pododermatitis, foul in the foot).

Sheep. Treatment of respiratory tract infections caused by Mannheimia haemolytica and Pasterurella multocida. It is also used in the treatment of foot rot caused by Dichelobacter nodosus and Fusobacterium necrophorum. It is also recommended for the treatment of ovine mastitis associated with Staphylococcus aureus and Mycoplasma agalactiae.

  • Hypersensitivity or resistance to tilmicosin;
  • Concurrent administration of other macrolides, lincosamides or ionophores;
  • Administration to equine, porcine or caprine species, or to lambs weighing 15 kg or less;
  • Administration to cattle producing milk for human consumption;
  • During pregnancy, use only after a risk/benefit assessment by a veterinarian. Do not use in heifers within 60 days of calving;
  • Using with adrenalin or β-adrenergic antagonists such as propranolol is not recommended.
Administration and Dosage

Inject subcutaneously in cattle and sheep only.

Usual dosage is as follows: 10-20mg of tilmicosin per kg body weight in cattle and sheep (as a single subcutaneous dose). In sheep greater than 15 kg, administer a single subcutaneous dose of 10 mg/kg of body weight (1 mL/30 kg or 1.5 mL per 100 lbs). Tilmicosin injection shouldn’t be administered if any hypersensitivity is discovered.

Do not inject more than 10 mL per injection site.

For cattle and sheep, injection under the skin in the neck is suggested. If not accessible, inject under the skin behind the shoulders and over the ribs.

Precise weighing of animals is important to avoid over dosage. The diagnosis should be reconfirmed if no improvement is noted within 48 h. Administer once only.

Refer to an animal care specialist for guidelines on dosage. Do not exceed what they advise, and complete the full treatment, as stopping early can result in a recurrence or worsening of the problem.


Intramuscular injection will cause a local reaction which may result in trim loss of edible tissue at slaughter.

The effects of tilmicosin have not been determined on bovine and ovine reproductive performance and during pregnancy and lactation.


Accurate weighing of lambs is important to avoid overdose. The use of a 2 ml or smaller syringe will facilitate accurate dosing.


In cattle. Whenever overdosed edema at the site of injection can be seen with light necrosis of the myocardium lesion. Other symptoms can be: difficulty in moving, reduced appetite and tachycardia.

In sheep. Overdosage may lead to increase in the respiration rate. Higher doses (150 mg/kg body weight) can cause ataxia, lethargy and the inability to raise the head. Deaths can occur after one single intravenous injection of 5 mg/kg body weight in cattle and 7.5 mg/kg in sheep body weight.


Interactions between macrolides and ionophores have been observed in some species.

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