*AdvaCare Procaine Penicillin G + Benzathine Penicillin Injections is GMP certified.

**AdvaCare Procaine Penicillin G + Benzathine Penicillin Injections is manufactured in our facilities located in China, India and USA.

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150000IU + 150000IU

*or according to the distributor/market composition


10ml vial/box;20ml vial/box;30ml vial/box;50ml vial/box;100ml vial/box;500ml vial/box

*or according to distributor/market requirements

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Product Information

General Information:
AdvaCare is a GMP manufacturer of Procaine Penicillin G + Benzathine Penicillin injections.

Procaine penicillin G + benzathine penicillin injection are narrow spectrum penicillins with a bactericidal action against Gram-positive and Gram-negative bacteria like Campylobacter, Clostridium, Corynebacterium, Erysipelothrix, Haemophilus, Listeria, Pasteurella, penicillinase negative Staphylococcus and Streptococcus spp.

It is used in the treatment of Arthritis, mastitis and gastrointestinal, respiratory and urinary tract infections caused by penicillin sensitive micro-organisms in calves, cattle, goats, sheep, and swine.

After intramuscular administration within 1 to 2 hours therapeutic blood levels are obtained. Because of the slow reabsorption of benzathine penicillin, the action is maintained for two days.

Side Effects:
As with all veterinary medicine, some unwanted effects can occur from the use of procaine penicillin G and benzathine penicillin injections. Always consult a veterinary physician or animal care specialist for medical advice before use.

With very high overdoses a diminished immune response can be observed.

Common side effects may include: abortion in sows (when overdosed), Ototoxicity, neurotoxicity or nephrotoxicity.

If you notice any serious effects or other effects not mentioned on this package, please inform your veterinary surgeon.

For a comprehensive list of all possible effects, consult a veterinary physician. If any symptom persists or gets worse, or you notice any other symptom, then please seek veterinary medical treatment immediately.

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Additional Information

Always consult a veterinary physician or animal care specialist before using procaine penicillin G and benzathine penicillin injections.

Indications and Usage

This product is indicated for the treatment of the following bacterial infections in beef cattle:

  • Bacterial Pneumonia (shipping fever complex) (Streptococcus spp., Actinomyces pyogenes, Staphylococcus aureus);
  • Upper Respiratory Infections such as rhinitis or pharyngitis (Actinomyces pyogenes) ;
  • Blackleg (Clostridium chauvoei).
  • Hypersensitivity to penicillin and/or procaine;
  • Administration to animals with a seriously impaired renal function;
  • Concurrent administration of tetracyclins, chloramphenicol, macrolides and lincosamides.
Administration and Dosage

Usual dosage is as follows: 2ml of procaine penicillin G and benzathine penicillin per 68kg body weight in beef cattle (subcutaneously only). Procaine penicillin G and benzathine penicillin injections shouldn’t be administered if any hypersensitivity is discovered.

Treatment in beef cattle should be limited to two (2) doses, given by subcutaneous injection only.

Refer to an animal care specialist for guidelines on dosage. Do not exceed what they advise, and complete the full treatment, as stopping early can result in a recurrence or worsening of the problem.

Treatment with the recommended dosage is usually given at a single session using multiple intramuscular sites when indicated. An alternative dosage schedule may be used, giving one-half (1/2) the total dose on day 1 and one-half (1/2) on day 3.


Exceeding the recommended dosage levels may result in antibiotic residues beyond the withdrawal time.

Animals administered penicillin G should be kept under close observation for at least one-half hour. Whenever any allergic reaction or hypersensitivity is discovered, discontinuation of the product is recommended.

As with all antibiotic preparations, use of this drug may result in overgrowth of non-susceptible organisms, including fungi. In such instances, consult a veterinarian.

It is advisable to avoid administering penicillin in conjunction with tetracyclines because some bacterial drugs may interfere with the bacteriostatic action of tetracyclines.


Beef cattle should be withheld from slaughter for consumption use for 30 days following the last treatment. Treatment in beef cattle must be limited to two (2) doses, by subcutaneous injection only. Do not inject intramuscularly.

A withdrawal period has not been established for this product in pre-ruminating calves. Using in calves for processing of meat is not recommended.


Over dosage of penicillin may lead to neuromuscular hyperirritability, convulsions or seizures. With very high overdoses a diminished immune response can be observed. However, if overdose is suspected, seek emergency medical attention.


Tetracycline is a bacteriostatic antibiotic which may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. Concurrent administration of penicillin and probenecid increases and prolongs serum penicillin levels and slowing the rate of excretion by competitively inhibiting renal tubular secretion of penicillin.

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