*AdvaCare Dipyrone Injections is GMP certified.

**AdvaCare Dipyrone Injections is manufactured in our facilities located in China, India and USA.

(choose the specifications you require below)

Dosage:

30%;50%

*or according to the distributor/market composition

Packaging:

10ml vial/box;20ml vial/box;30ml vial/box;50ml vial/box;100ml vial/box;500ml vial/box

*or according to distributor/market requirements

Therapy:

Analgesic

Active Ingredients:

Dipyrone

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Product Information

General Information:
AdvaCare is a GMP manufacturer of Dipyrone injections.

Dipyrone (metamizole) belongs to class of non-steroidal anti-inflammatory drug. The drug works by inhibiting the production of prostaglandins.

Dipyrone has anti-spasmodic properties on the smooth muscle of the gastrointestinal tract, which has been the basis for its common use in cases of mild colic.

Dipyrone may be used in foals and in adult horses to reduce fevers. It commonly is used as an antipyretic, analgesic and anti-inflammatory drug.

Side Effects:
As with all veterinary medicine, some unwanted effects can occur from the use of dipyrone injections.
Always consult a veterinary physician or animal care specialist for medical advice before use.

No side effects have been detected yet, a transient local reaction may occur at the site of injection. If you notice any serious effects or other effects not mentioned on this package, please inform your veterinary surgeon.

Prolonged use of dipyrone may cause bone-marrow suppression (leukopenia, agranulocytosis).

For a comprehensive list of all possible effects, consult a veterinary physician. If any symptom persists or gets worse, or you notice any other symptom, then please seek veterinary medical treatment immediately.

Additional Information

Always consult a veterinary physician or animal care specialist before using dipyrone injections.

Indications and Usage

Dipyrone is a very mild NSAID which has-spasmodic properties on the smooth muscle of the gastrointestinal tract which works for the treatment of colic (unexplained stomach pain). It is also used in controlling of diarrhea in cattle.

Dipyrone has anti-pyretic properties which help in reducing fever in foals and adult horses. It is also used in the pain management associated with urinary obstruction in horses and dogs.

Contraindications

Due to a risk of local reactions do not use the intramuscular route in horses. Do not use in animals with known hypersensitivity to the active ingredients. Do not use in horses suffering from paralytic ileus.

Administration and Dosage

Usual dosage is as follows: 20-50 mg/kg bw to horses, 20-40 mg/kg bw to cattle, 15-50 mg/kg bw to pigs by intravenous or intramuscular injection; and 1-5ml of dipyrone per kg body weight in dogs (intramuscularly, intravenously or subcutaneously). Dipyrone injections shouldn’t be administered if any hypersensitivity is discovered.

Completion of full treatment is always advisable with or without the presence of symptoms.

Refer to an animal care specialist for guidelines on dosage. Do not exceed what they advise, and complete the full treatment, as stopping early can result in a recurrence or worsening of the problem.

Precautions
  • Dipyrone is an NSAID which is given under supervision for animals with liver disease, kidney disease or GI problems. Discontinuation of therapy is recommended at the first sign of any adverse reaction such as anorexiaoral ulcers, depression, decreased plasma protein, increased creatinine, anemia or leukopenia;
  • Dipyrone should be given slowly administered. Rapid administration may cause seizures;
  • Dipyrone should be used with cautiousness in older or weak animals particularly those with cardiac disease;
  • It should not be used in animals with a history of blood or bone marrow abnormalities.

Studies in laboratory animals (rabbit, rat) have not produced any evidence of a teratogenic effect. No information on use during pregnancy in the target species is available and therefore this product should not be used.

Warnings

Avoid use of the product if you are sensitive to pyrazolones, or to aspirin. If accidental self-injection occurs, seek medical advice immediately.

Overdose

Severity of side effects is increased with the administration of overdose; convulsions have been reported following acute overdose.

Interactions

Interaction of atropine with chloropromazine which may lead to serious hypothermia. It also interacts with phenyl butazone or barbiturates leading to convulsions and seizures.

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