*AdvaCare Diphenhydramine Hydrochloride Injections is GMP certified.

**AdvaCare Diphenhydramine Hydrochloride Injections is manufactured in our facilities located in China, India and USA.

(choose the specifications you require below)

Dosage:

2.5%; 5%

*or according to the distributor/market composition

Packaging:

10ml vial/box;20ml vial/box;30ml vial/box;50ml vial/box;100ml vial/box;500ml vial/box

*or according to distributor/market requirements

Therapy:

Anti-allergic, Antiemetic

Active Ingredients:

Diphenhydramine

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Product Information

General Information:
AdvaCare is a GMP manufacturer of Diphenhydramine Hydrochloride injections.

Diphenhydramine injections are used as an antihistamine to treat life-threatening allergic reactions (anaphylaxis) along with epinephrine and other treatments.

Diphenhydramine injection is used for the treatment of acute inflammatory and allergic conditions in dogs and cats.

Diphenhydramine is also used as an antiemetic and frequently is used to prevent motion sickness in dogs. H1 histaminergic receptors play a role in the emetic response associated with motion sickness in dogs (but not in cats).

Diphenhydramine will cause some central nervous system (CNS) depression and sedation, although the sedative effects may diminish with time. When using oral diphenhydramine for motion sickness, it should be given 30 to 60 minutes before traveling.

Side Effects:
As with all veterinary medicine, some unwanted effects can occur from the use of diphenhydramine hydrochloride injections. Always consult a veterinary physician or animal care specialist for medical advice before use.

Common side effects include: sedation, dry mouth and urinary retention. Rare side effects include: diarrhea, vomiting and decreased appetite.

For a comprehensive list of all possible effects, consult a veterinary physician. If any symptom persists or gets worse, or you notice any other symptom, then please seek veterinary medical treatment immediately.

  • For more information about our Diphenhydramine Hydrochloride Injections
    email us at: [email protected]

Additional Information

Always consult a veterinary physician or animal care specialist before using diphenhydramine hydrochloride injections.

Indications and Usage

Diphenhydramine is used in the treatment of allergies in dogs. It belongs to the class of antihistamines which may also be used as an antiemetic and is used to prevent motion sickness in dogs. Antihistamines alone can control pruritis in 20-40% of atopic dogs.

It has H1 receptors which play a role in the emetic response associated with motion sickness in dogs (but not in cats). Diphenhydramine will cause some central nervous system (CNS) depression and sedation, although the sedative effects may diminish with time.

Diphenhydramine also is used to treat neurotoxicity or extrapyramidal effects due to phenothiazines, metoclopramide, and tremors due to organophosphate or carbamate poisoning.

Administration and Dosage

Administration of diphenhydramine hydrochloride in livestock is not advisable.

Usual dosage is as follows: 1-2 mg of diphenhydramine per kg body weight (intravenously, intramuscularly and subcutaneously) in dogs and cats. Diphenhydramine injections shouldn’t be administered if any hypersensitivity is discovered.

Refer to an animal care specialist for guidelines on dosage. Do not exceed what they advise, and complete the full treatment, as stopping early can result in a recurrence or worsening of the problem.

Completion of full treatment is always advisable with or without the presence of symptoms.

Precautions
  • The dose of diphenhydramine should be adjusted cording to the need of an individual animal because every animal may have different response towards antihistamines;
  • Antihistamines should be used with caution in working dogs due to its tranquilizing side effects;
  • Diphenhydramine should be used with caution in animals with prostatic hypertrophy, bladder neck obstruction, severe heart failure, angle closure glaucoma, pyeloduodenal obstruction, hyperthyroidism, seizure disorders and hypertension or allergic lung disease (COPD) ;
  • Older animals are more sensitive to side effects from antihistamines. A lower dose of diphenhydramine may be indicated in older animals.

High dosage of diphenhydramine can lead to birth defects in animals. Diphenhydramine is excreted in breast milk. It should not be used in pregnant or lactating animals.

Warnings

Keep away from children. Diphenhydramine should not be used with additional tranquilizing medications.

Overdose

Overdose with diphenhydramine can cause symptoms ranging from CNS stimulation to CNS depression.

Symptoms of overdose ranges from mild sedation and clumsiness to severe seizures, respiratory depression, coma ultimately death can occur after a massive overdose.

Interactions

Diphenhydramine may have a tranquilizing effect when combined with other CNS depressant drugs, such as barbiturates and tranquilizers or when combined with other anticholinergic agents. Diphenhydramine may interfere with neurotransmitters. It may decrease the effects of heparin and warfarin.

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