AdvaCare is a GMP manufacturer of Collagen softgels.
Collagen is the most abundant protein in the human body and is the substance that holds the whole body together. It is found in the bones, muscles, skin, and tendons, where it forms a scaffold to provide strength and structure.
Endogenously produced collagen (i.e. collagen synthesized by the body) plays numerous important roles in health, with the breakdown and depletion of the body’s natural collagen associated with a number of health problems. As such, exogenous (supplemental) collagen is increasingly used for medical and cosmetic purposes, including helping with healing and repairing of the body’s tissues.
Protein makes up around 20% of the body’s mass, and collagen makes up around 30% of the protein in the human body. There are at least 16 types of collagen, but 80-90% of the collagen in the body consists of types I, II, and III.
Type I collagen fibrils are stronger than steel (gram for gram).Collagen is most commonly found in the body of the skin, bones and connective tissues. The word “collagen” is derived from the Greek “kolla,” meaning glue. Collagen gives the skin its strength and structure and also plays a role in the replacement of dead skin cells.
Collagen production declines with age (as part of intrinsic aging), and is reduced by exposure to ultraviolet light and other environmental factors (extrinsic aging).Collagen in medical products can be derived from human, bovine, porcine and ovine sources. Collagen dressings attract new skin cells to wound sites. Cosmetic products such as revitalizing lotions that claim to increase collagen levels are unlikely to do so, as collagen molecules are too large to be absorbed through the skin. Collagen production can be stimulated through the use of laser therapy and the use of all-trans retinoic acid (a form of vitamin A). Controllable factors that damage the production of collagen include sunlight, smoking, and high sugar consumption.
While young, the body consistently produces collagen, but collagen synthesis begins to decline around the age of 40, with a dramatic reduction in synthesis in women after menopause. By the age of 60, there is typically a considerable decline in collagen production.