Always consult your doctor or pharmacist before taking tolbutamide.
Do NOT use tolbutamide if:
- You are allergic to any ingredient in tolbutamide;
- You have problems associated with diabetes or high blood acid levels.
Refer to your doctor or pharmacist for guidelines on dosage. Do not exceed what they advise. Initial dose: 1 to 2g orally once a day or in divided doses through the day; adjust dose based on blood glucose response; maintenance dose: 0.25 to 3g orally once a day or in divided doses through the day; maximum dose: 3g per day.
Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar. Rarely, alcohol can interact with tolbutamide and cause a serious reaction (disulfiram-like reaction) with symptoms such as facial flushing, nausea, vomiting, dizziness, or stomach pain.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).