*AdvaCare Benzathine Penicillin Powder for Injections is GMP certified.

**AdvaCare Benzathine Penicillin Powder for Injections is manufactured in our facilities located in China, India and USA.

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*or according to distributor/market composition


10 vials/box;50 vials/box

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Active Ingredients:

Benzathine Penicillin

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Product Information

General Information:
AdvaCare is a GMP manufacturer of Benzathine Penicillin powder for injections.

Penicillin G benzathine is a slow-onset antibiotic that fights bacteria in your body. Benzathine penicillin powder for injections is used to treat many different types of severe infections, including strep infections, rheumatic fever, and syphilis.

This medication is given by injection into a large muscle as directed by your doctor. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on age and weight.

If you are using this medication at home, learn all preparation and usage instructions from your healthcare professional. Do not inject into or near an artery, nerve, or vein.

Change the injection site each time to lessen injury to the muscle. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. If more than one dose is needed, receive this drug at evenly spaced intervals as prescribed by your doctor. Do not miss any doses.

Side Effects:
As with all pharmaceuticals, some unwanted effects can occur from the use of benzathine penicillin powder for injections. Always consult a doctor or health care professional for medical advice before use.

Common side effects include:

  • Nausea, vomiting;
  • Blurred vision, ringing in your ears;
  • Headache, dizziness;
  • Mild skin rash; or
  • Pain, swelling, bruising, skin changes, or a hard lump where the medicine was injected.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • Fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • Skin rash with bruising, severe tingling, numbness, pain, muscle weakness;
  • Rash or itching with swollen glands, joint pain, or general ill feeling;
  • Diarrhea that is watery or bloody;
  • Slow heart rate, weak pulse, fainting, slow breathing;
  • Fast or pounding heartbeats;
  • Uncontrolled muscle movements, problems with vision, speech, balance, thinking, or walking;
  • Confusion, agitation, hallucinations, unusual thoughts or behavior;
  • Easy bruising or bleeding, unusual weakness;
  • Pale or yellowed skin, dark colored urine; or
  • Urinating less than usual or not at all.

For a comprehensive list of all possible effects, consult your doctor.

If any symptom persists or gets worse, or you notice any other symptom, then please call your doctor immediately.

  • For more information about our Benzathine Penicillin Powder for Injections
    email us at: [email protected]

Additional Information

Always consult your doctor or pharmacist before taking benzathine penicillin powder for injections.

Indications and Usage

Benzylpenicillin is indicated for infections caused by wounds, pyogenic infections of the skin, soft tissue infections and infections of the nose, throat, nasal sinuses, respiratory tract and middle ear, etc.

It is also indicated for generalised infections, septicaemia and pyaemia from susceptible bacteria. Acute and chronic osteomyelitis, sub-acute bacterial endocarditis and meningitis caused by susceptible organisms.

It is also used in the treatment of suspected meningococcal disease, gas gangrene, tetanus, actinomycosis, anthrax, leptospirosis, rat-bite fever, listeriosis, severe Lyme disease, and prevention of neonatal group B streptococcal infections.

It is also used in the treatment to cure complications caused by gonorrhoea and syphilis, diphtheria, brain abscesses and pasteurellosis.


This drug is contraindicated in the patients who are cross allergic to beta-lactams such as cephalosporins.


Consult with your doctor about any medications you are taking, before your treatment with benzathine penicillin powder for injections.

Do not use benzathine penicillin powder for injections if you:

  • Have a history of allergy/ hypersensitivity towards antibiotic drugs or towards penicillin;
  • Have impaired renal function;
  • Have asthma, kidney problems, or liver problems;
  • Have diabetes;
  • Have pseudomemvranous colitis because it may lead to severe diarrhea.

There is little evidence with regards to the use of benzathine penicillin powder for injections during pregnancy or breast feeding, so consult your doctor or health care professional before using aminophylline. Theophylline can be excreted into breast milk, but it is unlikely to cause serious adverse reactions.

Administration and Dosage

The usual dose for adults is: 1 to 6 mega units daily, divided into 4 to 6 doses, depending on the indication. Higher doses can be up to 24 mega units in divided doses may be given in serious infections such as adult meningitis by the intravenous route.

The usual dose for children (1 month to 12 years) is: 100 mg/kg/day in 4 divided doses; not exceeding 4 g/day. The usual dose for infants (1-4 weeks) is: 75 mg/kg/day in 3 divided doses.

Refer to your doctor or pharmacist for guidelines on dosage. Do not exceed what they advise.


Benzathine penicillin may interact with other drugs such as probenecid (benemid), blood thinner such as warfarin, Methotrexate (Rheumatrex, Trexall); or tetracycline antibiotics, such as doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).


Symptoms of overdose include trouble breathing and passing out. These symptoms have to be reported to the medical health professional. Seek medical help urgently.

Adverse Reactions

Allergy to penecillin may occur rarely. A transient local reaction may occur in the place of application.

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