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Always consult your doctor or pharmacist before taking benzathine penicillin powder for injections.
Indications and Usage
Benzylpenicillin is indicated for infections caused by wounds, pyogenic infections of the skin, soft tissue infections and infections of the nose, throat, nasal sinuses, respiratory tract and middle ear, etc.
It is also indicated for generalised infections, septicaemia and pyaemia from susceptible bacteria. Acute and chronic osteomyelitis, sub-acute bacterial endocarditis and meningitis caused by susceptible organisms.
It is also used in the treatment of suspected meningococcal disease, gas gangrene, tetanus, actinomycosis, anthrax, leptospirosis, rat-bite fever, listeriosis, severe Lyme disease, and prevention of neonatal group B streptococcal infections.
It is also used in the treatment to cure complications caused by gonorrhoea and syphilis, diphtheria, brain abscesses and pasteurellosis.
This drug is contraindicated in the patients who are cross allergic to beta-lactams such as cephalosporins.
Consult with your doctor about any medications you are taking, before your treatment with benzathine penicillin powder for injections.
Do not use benzathine penicillin powder for injections if you:
- Have a history of allergy/ hypersensitivity towards antibiotic drugs or towards penicillin;
- Have impaired renal function;
- Have asthma, kidney problems, or liver problems;
- Have diabetes;
- Have pseudomemvranous colitis because it may lead to severe diarrhea.
There is little evidence with regards to the use of benzathine penicillin powder for injections during pregnancy or breast feeding, so consult your doctor or health care professional before using aminophylline. Theophylline can be excreted into breast milk, but it is unlikely to cause serious adverse reactions.
Administration and Dosage
The usual dose for adults is: 1 to 6 mega units daily, divided into 4 to 6 doses, depending on the indication. Higher doses can be up to 24 mega units in divided doses may be given in serious infections such as adult meningitis by the intravenous route.
The usual dose for children (1 month to 12 years) is: 100 mg/kg/day in 4 divided doses; not exceeding 4 g/day. The usual dose for infants (1-4 weeks) is: 75 mg/kg/day in 3 divided doses.
Refer to your doctor or pharmacist for guidelines on dosage. Do not exceed what they advise.
Benzathine penicillin may interact with other drugs such as probenecid (benemid), blood thinner such as warfarin, Methotrexate (Rheumatrex, Trexall); or tetracycline antibiotics, such as doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).
Symptoms of overdose include trouble breathing and passing out. These symptoms have to be reported to the medical health professional. Seek medical help urgently.
Allergy to penecillin may occur rarely. A transient local reaction may occur in the place of application.