Artesunate for Injection

Active Ingredients: Artesunate

Artesunate for Injection is an antimalarial drug used for the treatment of uncomplicated cases of malaria due to Plasmodium falciparum. Artesunate is generally well tolerated by patients and is a first-line treatment option for adults and children. This drug is not used for the prevention of malaria.

Artesunate has also been shown to have anti-cancer activity in the treatment of leukemia.

Artesunate is a water-soluble hemisuccinate derivative of dihydroartemisinin. It is one of the few artemisinin derivatives that is water soluble. It works by a combination of actions, including interfering with the heme group and increasing ROS (reactive oxygen species) and free radicals.

Artesunate for Injection is produced and exported as a combination kit with two diluents: 5% Sodium Bicarbonate and 0.9% Sodium Chloride. Sodium Bicarbonate helps improve the tolerability and safety of the medication, as it helps raise the pH of the reconstituted Artesunate. Sodium Chloride is a sterile solution in which the Artesunate can be dissolved, which also helps deliver electrolytes and fluids to the patient.

AdvaCare Pharma is a GMP-certified manufacturer of Artesunate for Injection. This medicine is produced in our facilities located in China, India, and the USA. Our manufacturing facilities are regularly inspected to ensure our products meet quality and safety standards.

AdvaCare Pharma, a US-owned pharmaceutical company, manufactures Artesunate for Injection at our GMP-compliant facilities located worldwide. We conduct periodic internal and third-party facility inspections to ensure that our products meet or surpass the requirements of our distributors. Our global reach extends to over 65 markets, where we supply a wide range of products to our partners, including distributors, hospitals, pharmacies, NGOs, and government institutions.

What is Artesunate used for?

It is used to treat falciparum malaria in adults and children.

How is Artesunate for Injection used?

This medication has been manufactured as a powder intended for reconstitution and packaged with two diluents. As an injectable form, it is to be administered directly into a vein or a muscle.

What dose should be given?

For adults and children, the usual dose is 2.4 mg of Artesunate per kg of body weight, by slow intravenous (IV) or deep intramuscular (IM) injection. Administer at 0, 12 and 24 hours, and then once daily until oral treatment can be substituted.

Artesunate Injection should be administered for a minimum of 24 hours (3 doses), regardless of the patient's ability to tolerate oral medication earlier. After at least 24 hours and when able to tolerate oral medication, the patient should be switched to a complete treatment course of an oral combination antimalarial regimen. Relevant treatment guidelines should be consulted when selecting an appropriate regimen.

As with all pharmaceuticals, some unwanted effects can occur from the use of Artesunate for Injection.

For a comprehensive list of all side effects, consult a doctor or pharmacist.

If any symptom persists or gets worse, or you notice any other symptoms, please call your doctor.

Do NOT use Artesunate for Injection if: • You are hypersensitive to Artesunate or any of the other ingredients.

Possible interactions with Artesunate may occur in combination with drugs like amodiaquine or efavirenz. Use caution with drugs such as axitinib, cannabidiol, carbamazepine, diclofenac, fluconazole, fosphenytoin, imatinib, rifampin, ritonavir, valproic acid, and vandetanib.

Artesunate should only be used during pregnancy if the benefits outweigh the risks.

Driving or operating machinery should be avoided, as this drug may cause dizziness.